Internet-delivered cognitive behavioral therapy is associated with distinct blood small RNA profiles in panic disorder
- 1Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Faculty of Mathematics and Science, and the Edmond and Lily Safra Ce
Abstract
Panic disorder associates with altered fear circuitry, autonomic dysregulation and stress-related immune perturbations, yet its molecular and treatment-response signatures remain poorly defined. Internet-delivered cognitive behavioral therapy (iCBT) is an effective first-line treatment with unexplained outcome variations across individuals. Here, we report altered profiles of small non-coding RNAs in peripheral blood mononuclear cells from panic disorder patients before and after iCBT, compared with longitudinally sampled healthy controls. Thirteen top-ranking microRNAs discriminated patients from controls and separated pre- and post-treatment states, both of which differed from controls. Correspondingly, baseline hsa-miR-125b-5p levels were significantly associated with post-iCBT symptom improvement. Transfer RNA-derived fragments (tRFs) showed even greater discriminatory power, with nuclear-Val-3'-tRF family members exhibiting a pronounced post-treatment shift. Pathway analyses of panic disorder-associated and CBT-responsive small RNA targets converged on immune-related pathways, supporting a role in inflammatory mechanisms and highlighting blood small non-coding RNAs as promising biomarkers of panic disorder and its therapeutic response.
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BibTeX
@misc{treidel2026internetdelivered,
title = {{Internet-delivered cognitive behavioral therapy is associated with distinct blood small RNA profiles in panic disorder}},
author = {S. Vaknine Treidel and A. Halaj and L. Mitzva and T. Goltser-Dubner and A. Strauss and B. Gelchinsky-Karagichev and D. Pevzner and O. Oz and R. Amer and M. Lavon and O. Gadish and E. R. Bennett and D. S. Greenberg and L. Carmel and S. Israel and R. Segman and J. D. Huppert and H. Soreq},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.03.749122},
url = {https://www.biorxiv.org/content/10.64898/2026.09.03.749122v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Internet-delivered cognitive behavioral therapy is associated with distinct blood small RNA profiles in panic disorder
AU - S. Vaknine Treidel
AU - A. Halaj
AU - L. Mitzva
AU - T. Goltser-Dubner
AU - A. Strauss
AU - B. Gelchinsky-Karagichev
AU - D. Pevzner
AU - O. Oz
AU - R. Amer
AU - M. Lavon
AU - O. Gadish
AU - E. R. Bennett
AU - D. S. Greenberg
AU - L. Carmel
AU - S. Israel
AU - R. Segman
AU - J. D. Huppert
AU - H. Soreq
PY - 2026
DA - 2026/09/03
PB - bioRxiv
DO - 10.64898/2026.09.03.749122
UR - https://www.biorxiv.org/content/10.64898/2026.09.03.749122v1
AB - Panic disorder associates with altered fear circuitry, autonomic dysregulation and stress-related immune perturbations, yet its molecular and treatment-response signatures remain poorly defined. Internet-delivered cognitive behavioral therapy (iCBT) is an effective first-line treatment with unexplained outcome variations across individuals. Here, we report altered profiles of small non-coding RNAs in peripheral blood mononuclear cells from panic disorder patients before and after iCBT, compared with longitudinally sampled healthy controls. Thirteen top-ranking microRNAs discriminated patients from controls and separated pre- and post-treatment states, both of which differed from controls. Correspondingly, baseline hsa-miR-125b-5p levels were significantly associated with post-iCBT symptom improvement. Transfer RNA-derived fragments (tRFs) showed even greater discriminatory power, with nuclear-Val-3'-tRF family members exhibiting a pronounced post-treatment shift. Pathway analyses of panic disorder-associated and CBT-responsive small RNA targets converged on immune-related pathways, supporting a role in inflammatory mechanisms and highlighting blood small non-coding RNAs as promising biomarkers of panic disorder and its therapeutic response.
ER -