The cleaved C-terminal domain of GmERS1-1 modulates cell cycle via GmACR1
- 1CAAS
Abstract
Ethylene signaling orchestrates plant development and stress adaptation, yet how post-translational modifications of its receptors coordinate growth regulation remains unresolved. Here, we uncover a proteolytic processing mechanism of the soybean ethylene receptor GmERS1-1 that directly gates cell cycle progression. The GmERS1-1 mutants exhibit elevated yield under field conditions, whereas overexpression suppresses growth and hypersensitizes plants to ethylene. Ethylene triggers nuclear translocation of C-terminal domain (GmERS1-1-CEND), which is indispensable for receptor function. Mechanistically, GmERS1-1-CEND scaffolds a trimeric complex with GmACR1 and GmCDK7, enforcing G2/M phase arrest, thereby decoupling cell division from canonical ethylene transcriptional responses. Strikingly, ethylene-induced cell cycle blockade during apple fruit maturation mirrors this pathway, suggesting deep conservation across angiosperms. Our work defines a receptor processing-dependent signaling axis that directly interlinks phytohormone perception with cell cycle control, proposing tunable targets (e.g., GmERS1-1 cleavage efficiency) for engineering crop architecture and productivity.
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BibTeX
@misc{chen2026cleaved,
title = {{The cleaved C-terminal domain of GmERS1-1 modulates cell cycle via GmACR1}},
author = {K. Chen and Y. Zhou and W. Tang and D. Wang and Y. Bai and C. Wang and W. Li and X. Li and D. Guo and M. Zhang and J. Yan and J. Guo and Y. Zhao and B. Shan and J. Chen and Z. Xu and Y. He and J. Ma and Q. Song and H. Li and L. Qiu and H. Wang and M. Chen and Y.-z. Ma},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.07.757225},
url = {https://www.biorxiv.org/content/10.64898/2026.10.07.757225v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - The cleaved C-terminal domain of GmERS1-1 modulates cell cycle via GmACR1
AU - K. Chen
AU - Y. Zhou
AU - W. Tang
AU - D. Wang
AU - Y. Bai
AU - C. Wang
AU - W. Li
AU - X. Li
AU - D. Guo
AU - M. Zhang
AU - J. Yan
AU - J. Guo
AU - Y. Zhao
AU - B. Shan
AU - J. Chen
AU - Z. Xu
AU - Y. He
AU - J. Ma
AU - Q. Song
AU - H. Li
AU - L. Qiu
AU - H. Wang
AU - M. Chen
AU - Y.-z. Ma
PY - 2026
DA - 2026/10/07
PB - bioRxiv
DO - 10.64898/2026.10.07.757225
UR - https://www.biorxiv.org/content/10.64898/2026.10.07.757225v1
AB - Ethylene signaling orchestrates plant development and stress adaptation, yet how post-translational modifications of its receptors coordinate growth regulation remains unresolved. Here, we uncover a proteolytic processing mechanism of the soybean ethylene receptor GmERS1-1 that directly gates cell cycle progression. The GmERS1-1 mutants exhibit elevated yield under field conditions, whereas overexpression suppresses growth and hypersensitizes plants to ethylene. Ethylene triggers nuclear translocation of C-terminal domain (GmERS1-1-CEND), which is indispensable for receptor function. Mechanistically, GmERS1-1-CEND scaffolds a trimeric complex with GmACR1 and GmCDK7, enforcing G2/M phase arrest, thereby decoupling cell division from canonical ethylene transcriptional responses. Strikingly, ethylene-induced cell cycle blockade during apple fruit maturation mirrors this pathway, suggesting deep conservation across angiosperms. Our work defines a receptor processing-dependent signaling axis that directly interlinks phytohormone perception with cell cycle control, proposing tunable targets (e.g., GmERS1-1 cleavage efficiency) for engineering crop architecture and productivity.
ER -