Taxonomy-Guided Discovery of Antiviral Resources in Korean Peucedanum L. (Apiaceae).
7 affiliations
- 1Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
- 2Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
- 3Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea.
- 4Department of Biology, Chungbuk National University, Cheongju 28644, Republic of Korea.
- 5Animal Medical Institute, Chonnam National University, Gwangju 61186, Republic of Korea.
- 6Department of Veterinary Anatomy, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
- 7Advanced-Basic-Convergence Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea.
Abstract
The genus Peucedanum (Apiaceae) contains diverse coumarins and related secondary metabolites with a wide range of pharmacological activities; however, the antiviral potential of Korean taxa remains largely unexplored. In this study, we evaluated the cytotoxicity and anti-influenza activity of aerial-part extracts from Korean Peucedanum taxa and the allied species Sillaphyton podagraria. Twenty-six ethanol extracts, comprising 24 accessions representing eight identified taxa and two unidentified Peucedanum samples, were screened against influenza A/Puerto Rico/8/34 (H1N1) virus in MDCK cells. Cytotoxicity and antiviral activity were assessed using MTT-based assays, and the half-maximal inhibitory concentration (IC₅₀), half-maximal cytotoxic concentration (CC₅₀), and selectivity index (SI) were determined. Most extracts showed low cytotoxicity, with CC₅₀ values > 100 μg/mL. P. terebinthaceum var. deltoideum showed the strongest and most consistent activity across all three accessions, with IC₅₀ values of 6.42 to 12.18 μg/mL and SI values ranging from >8.21 to >15.57. One P. japonicum extract (Pj2) was also active (IC₅₀ = 15.52 μg/mL; SI > 6.44). Comparative chromatographic profiling further revealed taxon-specific chemical patterns. Collectively, these findings identify P. terebinthaceum var. deltoideum as a promising source of antiviral compounds and highlight the utility of a taxonomy-guided approach for bioprospecting and natural-product-based antiviral discovery.
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BibTeX
@article{lee2026taxonomyguided,
title = {{Taxonomy-Guided Discovery of Antiviral Resources in Korean Peucedanum L. (Apiaceae).}},
author = {Gun Lee and Kyeonghee Kim and Seung Mok Ryu and Heewon Ji and Hyun Ji Lee and Hyeon Jeong Moon and Chung-Do Lee and Jaewoo Choi and Yeong-Bin Baek and Sang-Ik Park and Joong-Sun Kim and Jun-Gyu Park and Jun-Ho Song},
journal = {International journal of molecular sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27198676},
url = {https://europepmc.org/article/MED/42883922},
note = {CC BY},
}
RIS
TY - JOUR
TI - Taxonomy-Guided Discovery of Antiviral Resources in Korean Peucedanum L. (Apiaceae).
AU - Gun Lee
AU - Kyeonghee Kim
AU - Seung Mok Ryu
AU - Heewon Ji
AU - Hyun Ji Lee
AU - Hyeon Jeong Moon
AU - Chung-Do Lee
AU - Jaewoo Choi
AU - Yeong-Bin Baek
AU - Sang-Ik Park
AU - Joong-Sun Kim
AU - Jun-Gyu Park
AU - Jun-Ho Song
PY - 2026
DA - 2026/09/28
JO - International journal of molecular sciences
DO - 10.3390/ijms27198676
UR - https://europepmc.org/article/MED/42883922
AB - The genus Peucedanum (Apiaceae) contains diverse coumarins and related secondary metabolites with a wide range of pharmacological activities; however, the antiviral potential of Korean taxa remains largely unexplored. In this study, we evaluated the cytotoxicity and anti-influenza activity of aerial-part extracts from Korean Peucedanum taxa and the allied species Sillaphyton podagraria. Twenty-six ethanol extracts, comprising 24 accessions representing eight identified taxa and two unidentified Peucedanum samples, were screened against influenza A/Puerto Rico/8/34 (H1N1) virus in MDCK cells. Cytotoxicity and antiviral activity were assessed using MTT-based assays, and the half-maximal inhibitory concentration (IC₅₀), half-maximal cytotoxic concentration (CC₅₀), and selectivity index (SI) were determined. Most extracts showed low cytotoxicity, with CC₅₀ values > 100 μg/mL. P. terebinthaceum var. deltoideum showed the strongest and most consistent activity across all three accessions, with IC₅₀ values of 6.42 to 12.18 μg/mL and SI values ranging from >8.21 to >15.57. One P. japonicum extract (Pj2) was also active (IC₅₀ = 15.52 μg/mL; SI > 6.44). Comparative chromatographic profiling further revealed taxon-specific chemical patterns. Collectively, these findings identify P. terebinthaceum var. deltoideum as a promising source of antiviral compounds and highlight the utility of a taxonomy-guided approach for bioprospecting and natural-product-based antiviral discovery.
SN - 1422-0067
ER -