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Peer-reviewedCC BYExperimental dermatology

Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?

  • Ines Martic1,2
  • Alessandro Paolini3
  • Stefania Paola Bruno3
  • Andrea Gallego4
  • Dorottya Ádám5
  • Sedat Odabas6,7
  • Şebnem Erçelen Ceylan8
  • Emanuela Camera9
  • Paloma Pérez4
  • Attila Oláh5
  • Andrea Masotti3
  • Mirjana Nacka-Aleksić10,11
3 more authors
  • Danuta Gutowska-Owsiak11
  • Nsrein Ali12
  • Maria Cavinato1,2
12 affiliations
  1. 1Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
  2. 2Center for Molecular Biosciences, Innsbruck, Austria.
  3. 3Research Laboratories, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
  4. 4Instituto de Biomedicina de Valencia IBV-CSIC, Valencia, Spain.
  5. 5Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
  6. 6Biomaterials and Tissue Engineering Laboratory (bteLAB), Department of Chemistry, Faculty of Science, Ankara University, Ankara, Türkiye.
  7. 7Interdisciplinary Research Unit for Advanced Materials (INTRAM), Ankara University, Ankara, Türkiye.
  8. 8Department of Biophysics, Hamidiye Faculty of Medicine, University of Health Sciences, İstanbul, Türkiye.
  9. 9Laboratory of Cutaneous Physiopathology, San Gallicano Dermatological Institute - IRCCS, Rome, Italy.
  10. 10Institute for the Application of Nuclear Energy (INEP), Department of Reproductive Biology, University of Belgrade, Zemun, Serbia.
  11. 11Laboratory of Experimental and Translational Immunology, Intercollegiate Faculty of Biotechnology of the University of Gdańsk and the Medical University of Gdańsk, UG Institute of Biotechnology, Gdańsk, Poland.
  12. 12Research Unit of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.
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Abstract

Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and cancer. We explore the mechanistic contributions of EVs derived from skin, emphasizing their influence on immune modulation, senescence and tissue regeneration. We also examine their potential as diagnostic biomarkers and therapeutic agents, while addressing key technical and conceptual challenges that limit clinical translation. Drawing on collaborative insights from the COST Action NETSKINMODELS, we provide a set of recommendations to advance the field, including standardizing separation protocols, improving functional characterization and integrating with emerging technologies such as microneedles and 3D bioprinting. Together, these perspectives outline a strategic framework for unlocking the diagnostic and therapeutic potential of EVs in dermatological research and clinical care.

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Cite

BibTeXRIS
BibTeX
@article{martic2026extracellular,
  title = {{Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?}},
  author = {Ines Martic and Alessandro Paolini and Stefania Paola Bruno and Andrea Gallego and Dorottya Ádám and Sedat Odabas and Şebnem Erçelen Ceylan and Emanuela Camera and Paloma Pérez and Attila Oláh and Andrea Masotti and Mirjana Nacka-Aleksić and Danuta Gutowska-Owsiak and Nsrein Ali and Maria Cavinato},
  journal = {Experimental dermatology},
  year = {2026},
  month = nov,
  doi = {10.1111/exd.70375},
  url = {https://europepmc.org/article/MED/42969279},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?
AU  - Ines Martic
AU  - Alessandro Paolini
AU  - Stefania Paola Bruno
AU  - Andrea Gallego
AU  - Dorottya Ádám
AU  - Sedat Odabas
AU  - Şebnem Erçelen Ceylan
AU  - Emanuela Camera
AU  - Paloma Pérez
AU  - Attila Oláh
AU  - Andrea Masotti
AU  - Mirjana Nacka-Aleksić
AU  - Danuta Gutowska-Owsiak
AU  - Nsrein Ali
AU  - Maria Cavinato
PY  - 2026
DA  - 2026/11/01
JO  - Experimental dermatology
DO  - 10.1111/exd.70375
UR  - https://europepmc.org/article/MED/42969279
AB  - Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and cancer. We explore the mechanistic contributions of EVs derived from skin, emphasizing their influence on immune modulation, senescence and tissue regeneration. We also examine their potential as diagnostic biomarkers and therapeutic agents, while addressing key technical and conceptual challenges that limit clinical translation. Drawing on collaborative insights from the COST Action NETSKINMODELS, we provide a set of recommendations to advance the field, including standardizing separation protocols, improving functional characterization and integrating with emerging technologies such as microneedles and 3D bioprinting. Together, these perspectives outline a strategic framework for unlocking the diagnostic and therapeutic potential of EVs in dermatological research and clinical care.
SN  - 0906-6705
SN  - 1600-0625
ER  -