Peer-reviewedCC BY 4.0International Journal of Molecular Sciences
BRCA1 Promoter Methylation Marks a Shared Blood Methylome State in Women with and Without Breast Cancer
4 affiliations
- 1Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 70-204 Szczecin, Poland
- 2Regional Center for Digital Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland
- 3The Independent Clinical Epigenetics Laboratory, Pomeranian Medical University, 70-204 Szczecin, Poland
- 4Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, 70-204 Szczecin, Poland
Abstract
Aberrant DNA methylation in peripheral blood has been proposed as a marker of breast cancer (BC) susceptibility. To determine whether BRCA1 promoter methylation reflects a broader constitutional methylation state, we performed genome-wide DNA methylation profiling in peripheral blood from 24 women with triple-negative breast cancer (TNBC) and 35 healthy controls, all carrying BRCA1 promoter methylation. Analysis using the Infinium MethylationEPIC BeadChip revealed no significant differences in global methylation patterns between groups. These findings suggest that BRCA1 promoter methylation represents a shared epigenetic state established before disease onset and largely unaffected by subsequent breast cancer development.
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BibTeX
@article{prajzendanc2026brca1,
title = {{BRCA1 Promoter Methylation Marks a Shared Blood Methylome State in Women with and Without Breast Cancer}},
author = {Karolina Prajzendanc and Katarzyna Ewa Sokołowska and Tomasz Kazimierz Wojdacz and Jan Lubiński and Jacek Gronwald and Anna Jakubowska},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27209289},
url = {https://www.mdpi.com/1422-0067/27/20/9289},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - BRCA1 Promoter Methylation Marks a Shared Blood Methylome State in Women with and Without Breast Cancer
AU - Karolina Prajzendanc
AU - Katarzyna Ewa Sokołowska
AU - Tomasz Kazimierz Wojdacz
AU - Jan Lubiński
AU - Jacek Gronwald
AU - Anna Jakubowska
PY - 2026
DA - 2026/10/01
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27209289
UR - https://www.mdpi.com/1422-0067/27/20/9289
AB - Aberrant DNA methylation in peripheral blood has been proposed as a marker of breast cancer (BC) susceptibility. To determine whether BRCA1 promoter methylation reflects a broader constitutional methylation state, we performed genome-wide DNA methylation profiling in peripheral blood from 24 women with triple-negative breast cancer (TNBC) and 35 healthy controls, all carrying BRCA1 promoter methylation. Analysis using the Infinium MethylationEPIC BeadChip revealed no significant differences in global methylation patterns between groups. These findings suggest that BRCA1 promoter methylation represents a shared epigenetic state established before disease onset and largely unaffected by subsequent breast cancer development.
SN - 1422-0067
ER -