Pulmonary Involvement in Chronic Lymphocytic Leukemia: A Structured Diagnostic Approach to Diffuse Infiltrates-A Case Report.
- 1Department of Respiratory Medicine Limoges University Hospital University of Limoges Limoges France.
- 2Department of Hematology and Cellular Therapy University Hospital of Limoges Limoges France.
- 3Reference Center for Primary Amyloidosis and Other Immunoglobulin Deposition Diseases University Hospital of Limoges Limoges France.
Abstract
Pulmonary abnormalities in chronic lymphocytic leukemia (CLL) usually reflect infection, pleural effusion, treatment toxicity, second malignancy, or Richter transformation. Leukemic pulmonary infiltration is underrecognized and radiologically heterogeneous. A 64-year-old man with CLL developed dyspnea, cough, and bilateral basal crazy-paving opacities on high-resolution computed tomography. Bronchoalveolar lavage showed lymphocytosis and a CD5-positive monoclonal B-cell population. Transbronchial lung cryobiopsy supported CLL infiltration and argued against mantle-cell lymphoma or transformation. Obinutuzumab plus venetoclax was followed by clinical improvement and regression of the interstitial lung opacities on follow-up imaging. This case supports combining BAL flow cytometry with tissue confirmation in this unusual pulmonary presentation. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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BibTeX
@article{aguado2026pulmonary,
title = {{Pulmonary Involvement in Chronic Lymphocytic Leukemia: A Structured Diagnostic Approach to Diffuse Infiltrates-A Case Report.}},
author = {Benoit Aguado and Florent Favard and Thomas Egenod and Pedro De Lima Prata and Arnaud Jaccard},
journal = {EJHaem},
year = {2026},
month = oct,
doi = {10.1002/jha2.70430},
url = {https://europepmc.org/article/MED/42910155},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Pulmonary Involvement in Chronic Lymphocytic Leukemia: A Structured Diagnostic Approach to Diffuse Infiltrates-A Case Report.
AU - Benoit Aguado
AU - Florent Favard
AU - Thomas Egenod
AU - Pedro De Lima Prata
AU - Arnaud Jaccard
PY - 2026
DA - 2026/10/21
JO - EJHaem
DO - 10.1002/jha2.70430
UR - https://europepmc.org/article/MED/42910155
AB - Pulmonary abnormalities in chronic lymphocytic leukemia (CLL) usually reflect infection, pleural effusion, treatment toxicity, second malignancy, or Richter transformation. Leukemic pulmonary infiltration is underrecognized and radiologically heterogeneous. A 64-year-old man with CLL developed dyspnea, cough, and bilateral basal crazy-paving opacities on high-resolution computed tomography. Bronchoalveolar lavage showed lymphocytosis and a CD5-positive monoclonal B-cell population. Transbronchial lung cryobiopsy supported CLL infiltration and argued against mantle-cell lymphoma or transformation. Obinutuzumab plus venetoclax was followed by clinical improvement and regression of the interstitial lung opacities on follow-up imaging. This case supports combining BAL flow cytometry with tissue confirmation in this unusual pulmonary presentation. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
SN - 2688-6146
ER -