Inter-Organ Communication in Adipose Tissue Homeostasis: Roles of Skeletal Muscle, Brain, and Heart-Derived Secretory Factors and Signalling Factors.
- 1Department of Pharmacology, Shandong Medical and Pharmaceutical University, Yantai, People's Republic of China.
- 2Department of Pharmacy, Yanbian University Hospital, Yanbian University, Yanji, People's Republic of China.
- 3Department of Endocrinology, The Second Clinical Medical College, Shandong Medical and Pharmaceutical University, Yantai, People's Republic of China.
Abstract
Adipose tissue functions not only as the primary site for energy storage but also as a critical endocrine organ that orchestrates systemic metabolic homeostasis. In recent years, inter-organ communication has emerged as a fundamental mechanism governing adipose tissue function and homeostasis. The skeletal muscle, brain, and heart-either independently or in concert-serve as key secretory and signaling organs, modulating adipocyte lipid metabolism, lipolysis, and thermogenesis through the release of diverse signaling molecules, including myokines, neuropeptides, cardiotrophins, and extracellular vesicles. This review systematically summarizes the latest research advances on secreted factors from these three major organs in the regulation of adipose tissue homeostasis, focusing on their molecular mechanisms underlying lipid metabolism, white adipose browning, and brown adipose thermogenesis. This article is targeted to provide theoretical insights into the integrated mechanisms of inter-organ communication in adipose tissue regulation and to offer exploratory perspectives on candidate targets for future therapeutic development in obesity and related metabolic disorders.
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BibTeX
@article{zhang2026interorgan,
title = {{Inter-Organ Communication in Adipose Tissue Homeostasis: Roles of Skeletal Muscle, Brain, and Heart-Derived Secretory Factors and Signalling Factors.}},
author = {Hanru Zhang and Xidong Yang and Yulin Wu and Min Wang and Yuxuan Yang and Xixi Chen and Jingxuan Wang and Haijing Yan and Yong Xu and Qingsong Jin and Yongjun Jin and Meizi Yang},
journal = {Diabetes, metabolic syndrome and obesity : targets and therapy},
year = {2026},
month = nov,
doi = {10.2147/dmso.s651843},
url = {https://europepmc.org/article/MED/42999846},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Inter-Organ Communication in Adipose Tissue Homeostasis: Roles of Skeletal Muscle, Brain, and Heart-Derived Secretory Factors and Signalling Factors.
AU - Hanru Zhang
AU - Xidong Yang
AU - Yulin Wu
AU - Min Wang
AU - Yuxuan Yang
AU - Xixi Chen
AU - Jingxuan Wang
AU - Haijing Yan
AU - Yong Xu
AU - Qingsong Jin
AU - Yongjun Jin
AU - Meizi Yang
PY - 2026
DA - 2026/11/03
JO - Diabetes, metabolic syndrome and obesity : targets and therapy
DO - 10.2147/dmso.s651843
UR - https://europepmc.org/article/MED/42999846
AB - Adipose tissue functions not only as the primary site for energy storage but also as a critical endocrine organ that orchestrates systemic metabolic homeostasis. In recent years, inter-organ communication has emerged as a fundamental mechanism governing adipose tissue function and homeostasis. The skeletal muscle, brain, and heart-either independently or in concert-serve as key secretory and signaling organs, modulating adipocyte lipid metabolism, lipolysis, and thermogenesis through the release of diverse signaling molecules, including myokines, neuropeptides, cardiotrophins, and extracellular vesicles. This review systematically summarizes the latest research advances on secreted factors from these three major organs in the regulation of adipose tissue homeostasis, focusing on their molecular mechanisms underlying lipid metabolism, white adipose browning, and brown adipose thermogenesis. This article is targeted to provide theoretical insights into the integrated mechanisms of inter-organ communication in adipose tissue regulation and to offer exploratory perspectives on candidate targets for future therapeutic development in obesity and related metabolic disorders.
SN - 1178-7007
ER -