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Peer-reviewedCC BY-NC-NDCurrent microbiology

The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications.

  • Jiaxue Feng1,2
  • Wenwen Xie1,2
  • Huifei Lu3
  • Li Tian1,2
  • Xiaohang Shi1,2
  • Jianbin Huang1,2
  • Xianhai Zeng1,2
  • Yichi Zhou4
  • Meizhen Zhao5,6
  • Baohui Cheng7,8
  • Haotao Zeng9,10
10 affiliations
  1. 1Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China.
  2. 2Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China.
  3. 3The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
  4. 4Department of Gastroenterology, Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, China. [email protected].
  5. 5Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. [email protected].
  6. 6Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. [email protected].
  7. 7Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. [email protected].
  8. 8Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. [email protected].
  9. 9Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. [email protected].
  10. 10Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. [email protected].
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Abstract

Intestinal barrier damage is a pivotal mediator of gut-organ crosstalk and a key contributor to systemic disease. This review systematically summarizes the structural organization of the intestinal barrier, including the mucus layer, epithelial tight junctions, and the lamina propria immune network, and highlights their coordinated roles in regulating intestinal barrier dysfunction and immune homeostasis. Disruption of barrier integrity facilitates the translocation of microbial products, cytokines, and metabolites, thereby promoting systemic inflammation and the pathogenesis of multi-organ diseases, including liver injury, pancreatitis, and cardiovascular disorders. Emerging evidence underscores the critical roles of gut microbiota, immune signaling pathways, and metabolic factors in barrier regulation. Advances in single-cell and spatial omics, together with artificial intelligence (AI)-driven multi-omics integration, are providing novel insights into the cellular heterogeneity and molecular mechanisms underlying barrier dysfunction. Therapeutic strategies targeting barrier restoration-including microbiota-based interventions and pharmacological approaches-show promising potential but require further clinical validation. This review provides a comprehensive framework for understanding intestinal barrier biology and its translational relevance.

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Cite

BibTeXRIS
BibTeX
@article{feng2026crosstalk,
  title = {{The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications.}},
  author = {Jiaxue Feng and Wenwen Xie and Huifei Lu and Li Tian and Xiaohang Shi and Jianbin Huang and Xianhai Zeng and Yichi Zhou and Meizhen Zhao and Baohui Cheng and Haotao Zeng},
  journal = {Current microbiology},
  year = {2026},
  month = oct,
  doi = {10.1007/s00284-026-05170-z},
  url = {https://europepmc.org/article/MED/42905293},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications.
AU  - Jiaxue Feng
AU  - Wenwen Xie
AU  - Huifei Lu
AU  - Li Tian
AU  - Xiaohang Shi
AU  - Jianbin Huang
AU  - Xianhai Zeng
AU  - Yichi Zhou
AU  - Meizhen Zhao
AU  - Baohui Cheng
AU  - Haotao Zeng
PY  - 2026
DA  - 2026/10/21
JO  - Current microbiology
DO  - 10.1007/s00284-026-05170-z
UR  - https://europepmc.org/article/MED/42905293
AB  - Intestinal barrier damage is a pivotal mediator of gut-organ crosstalk and a key contributor to systemic disease. This review systematically summarizes the structural organization of the intestinal barrier, including the mucus layer, epithelial tight junctions, and the lamina propria immune network, and highlights their coordinated roles in regulating intestinal barrier dysfunction and immune homeostasis. Disruption of barrier integrity facilitates the translocation of microbial products, cytokines, and metabolites, thereby promoting systemic inflammation and the pathogenesis of multi-organ diseases, including liver injury, pancreatitis, and cardiovascular disorders. Emerging evidence underscores the critical roles of gut microbiota, immune signaling pathways, and metabolic factors in barrier regulation. Advances in single-cell and spatial omics, together with artificial intelligence (AI)-driven multi-omics integration, are providing novel insights into the cellular heterogeneity and molecular mechanisms underlying barrier dysfunction. Therapeutic strategies targeting barrier restoration-including microbiota-based interventions and pharmacological approaches-show promising potential but require further clinical validation. This review provides a comprehensive framework for understanding intestinal barrier biology and its translational relevance.
SN  - 0343-8651
SN  - 1432-0991
ER  -