Peer-reviewedCC BY-NC-NDInternal Medicine
Atypical Anorexia Nervosa Developed in a Patient with Severe Obesity and Type 2 Diabetes Following Sleeve Gastrectomy and Postoperative Treatment with Semaglutide and Tirzepatide
Abstract
We describe an unusual case of a 60-year-old Japanese woman who developed atypical anorexia nervosa (AN) after undergoing bariatric surgery and postoperative semaglutide and tirzepatide therapy. At 57 years of age, due to severe obesity with a body weight of 113 kg (BMI 47.0), she underwent laparoscopic sleeve gastrectomy, and semaglutide and tirzepatide were started one month after surgery. Three years post-surgery, her weight drastically decreased to 50.3 kg (BMI: 20.9). Her rapid weight reduction, intense fear of weight gain, obsession with her body image, and normal weight (BMI >18.5) led to the diagnosis of atypical AN according to the DSM-5.
Related
- Tirzepatide for Weight Recurrence After Metabolic and Bariatric Surgery: A Critical Review of Direct and Indirect Evidence with Emphasis on Sleeve Gastrectomy, Nutritional Safety, and Clinical Implications
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- Semaglutide and Tirzepatide Suppress Hepatic Fatty Acid Uptake and Fatty Acid β-Oxidation in High-Fat Diet-Induced Obesity Mice.
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BibTeX
@article{saito2026atypical,
title = {{Atypical Anorexia Nervosa Developed in a Patient with Severe Obesity and Type 2 Diabetes Following Sleeve Gastrectomy and Postoperative Treatment with Semaglutide and Tirzepatide}},
author = {Chiaki Saito and Masahiro Saito and Masatoshi Nakagawa and Toshie Iijima and Takuya Tomaru and Teruo Jojima and Isao Usui and Norio Yasui-Furukori and Kazuyuki Kojima and Yoshimasa Aso},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.7502-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7502-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Atypical Anorexia Nervosa Developed in a Patient with Severe Obesity and Type 2 Diabetes Following Sleeve Gastrectomy and Postoperative Treatment with Semaglutide and Tirzepatide
AU - Chiaki Saito
AU - Masahiro Saito
AU - Masatoshi Nakagawa
AU - Toshie Iijima
AU - Takuya Tomaru
AU - Teruo Jojima
AU - Isao Usui
AU - Norio Yasui-Furukori
AU - Kazuyuki Kojima
AU - Yoshimasa Aso
PY - 2026
DA - 2026/08/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.7502-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7502-26/_article
AB - We describe an unusual case of a 60-year-old Japanese woman who developed atypical anorexia nervosa (AN) after undergoing bariatric surgery and postoperative semaglutide and tirzepatide therapy. At 57 years of age, due to severe obesity with a body weight of 113 kg (BMI 47.0), she underwent laparoscopic sleeve gastrectomy, and semaglutide and tirzepatide were started one month after surgery. Three years post-surgery, her weight drastically decreased to 50.3 kg (BMI: 20.9). Her rapid weight reduction, intense fear of weight gain, obsession with her body image, and normal weight (BMI >18.5) led to the diagnosis of atypical AN according to the DSM-5.
SN - 1349-7235
SN - 0918-2918
ER -