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Peer-reviewedCC BY 4.0The Journal of Neuroscience

Late UP-state Bias in Cortico-amygdalar Coordination

  • Yu Sato1
  • Tetsuhiko Kashima1
  • Shota Morikawa1,2
  • Haruki Takeuchi1,2
  • Yuji Ikegaya1,3,4
4 affiliations
  1. 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
  2. 2Graduate School of Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
  3. 3Institute for AI and Beyond, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
  4. 4Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita City, Osaka 565-0871, Japan
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Abstract

Neocortical slow oscillations temporally organize neuronal activity across distributed brain regions, but the coordination of basolateral amygdala (BLA) activity with these oscillations remains unclear. We investigated BLA neuronal activity relative to neocortical slow oscillations in male mice, primarily under urethane anesthesia. These oscillations are characterized by rhythmic alternation between active (UP) and inactive (DOWN) states at 0.3–3 Hz. Using unit recordings and calcium imaging, we found that BLA neuronal activity was sparse but preferentially associated with the later phase of the neocortical UP state, while calcium activity showed local spatial organization with greater synchronization among nearby neurons. Medial prefrontal cortical neurons projecting to the BLA were more likely to continue firing into the late phase of the UP state than other prefrontal neurons. Deep whole-cell recordings revealed transient depolarizations in BLA neurons preferentially during the late phase of UP states. Both the probability and timing of these depolarizations varied with UP-state duration, and voltage-clamp recordings revealed temporally anticorrelated changes in excitatory and inhibitory conductances. Thus, these findings define a temporally structured and probabilistic mode of neocortex–BLA coordination during slow oscillations.

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Cite

BibTeXRIS
BibTeX
@article{sato2026late,
  title = {{Late UP-state Bias in Cortico-amygdalar Coordination}},
  author = {Yu Sato and Tetsuhiko Kashima and Shota Morikawa and Haruki Takeuchi and Yuji Ikegaya},
  journal = {The Journal of Neuroscience},
  year = {2026},
  month = oct,
  doi = {10.1523/jneurosci.0449-26.2026},
  url = {https://doi.org/10.1523/jneurosci.0449-26.2026},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Late UP-state Bias in Cortico-amygdalar Coordination
AU  - Yu Sato
AU  - Tetsuhiko Kashima
AU  - Shota Morikawa
AU  - Haruki Takeuchi
AU  - Yuji Ikegaya
PY  - 2026
DA  - 2026/10/06
JO  - The Journal of Neuroscience
DO  - 10.1523/jneurosci.0449-26.2026
UR  - https://doi.org/10.1523/jneurosci.0449-26.2026
AB  - Neocortical slow oscillations temporally organize neuronal activity across distributed brain regions, but the coordination of basolateral amygdala (BLA) activity with these oscillations remains unclear. We investigated BLA neuronal activity relative to neocortical slow oscillations in male mice, primarily under urethane anesthesia. These oscillations are characterized by rhythmic alternation between active (UP) and inactive (DOWN) states at 0.3–3 Hz. Using unit recordings and calcium imaging, we found that BLA neuronal activity was sparse but preferentially associated with the later phase of the neocortical UP state, while calcium activity showed local spatial organization with greater synchronization among nearby neurons. Medial prefrontal cortical neurons projecting to the BLA were more likely to continue firing into the late phase of the UP state than other prefrontal neurons. Deep whole-cell recordings revealed transient depolarizations in BLA neurons preferentially during the late phase of UP states. Both the probability and timing of these depolarizations varied with UP-state duration, and voltage-clamp recordings revealed temporally anticorrelated changes in excitatory and inhibitory conductances. Thus, these findings define a temporally structured and probabilistic mode of neocortex–BLA coordination during slow oscillations.
SN  - 0270-6474
SN  - 1529-2401
ER  -