An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine
Abstract
Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.
Related
- TasTY: Development and evaluation of a taste test for quantifying taste sensitivity among preschool children-test-retest reliability, application, and comparison between children with and without prior SARS-CoV-2 infection.
- Peripheral blood transcriptomes and a single-cell atlas suggest a monocyte-associated immune recovery-failure axis in STEMI
- Replacing EEG with peripheral physiological signals for driving behavior recognition: a physiology-informed multimodal approach
- Orexins and neuregulins as exemplars of peptide physiology in the brain: experimental challenges and implications for neuropathology
- Effects of different shading levels on growth, physiology and leaf surface micromorphology of Sorbus sibirica "Dong Hong" seedlings
BibTeX
@misc{nanini2026open,
title = {{An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine}},
author = {Santino Nanini and Arnaud Wiedemann and Yassir Mamouni and Cyril Schweitzer and Philippe Jouvet and Michael Sauthier},
howpublished = {arXiv},
year = {2026},
month = oct,
doi = {10.48550/arxiv.2610.28517},
eprint = {2610.28517},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2610.28517},
}
RIS
TY - UNPB
TI - An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine
AU - Santino Nanini
AU - Arnaud Wiedemann
AU - Yassir Mamouni
AU - Cyril Schweitzer
AU - Philippe Jouvet
AU - Michael Sauthier
PY - 2026
DA - 2026/10/20
PB - arXiv
DO - 10.48550/arxiv.2610.28517
UR - https://arxiv.org/abs/2610.28517
AB - Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.
ER -