NIR-triggered gelatin-based hydrogel for ion-mechanical synergistic antibacterial therapy and infected wound closure.
6 affiliations
- 1Department of Clinical Pharmacy, The No.2 Hospital of Baoding Baoding 071052 People's Republic of China.
- 2School of Mechanical Engineering, Dalian University of Technology Dalian 116024 China.
- 3School of Physics and Materials, Nanchang University Nanchang 330031 China.
- 4College of Stomatology, North China University of Science and Technology Tangshan 063200 People's Republic of China [email protected].
- 5Respiratory Medicine, The No.2 Hospital of Baoding Baoding 071052 People's Republic of China [email protected].
- 6Department of Stomatology, The No.2 Hospital of Baoding Baoding 071052 People's Republic of China.
Abstract
Bacterial infection and impaired wound closure remain the leading causes of refractory cutaneous wound healing disorders, inflicting substantial global morbidity and mortality while exacerbating the crisis of antibacterial resistance. Infected cutaneous wounds present a persistent clinical difficulty, given that bacterial infection and inadequate wound closure exacerbate one another. Here, we constructed a hydrogel platform that integrates antibacterial activity and active wound closure through ion-mechanical coupling. The system combines thermoresponsive, catechol-functionalized network with core-shell nanoparticles consisting of a metal-organic framework shell (MOF) encapsulating a liquid metal core (LM). Under near-infrared (NIR) irradiation, the liquid metal generates heat that triggers network contraction to mechanically close the wound. Simultaneously, sustained release of Zn²⁺ and Ga³⁺ from the nanoparticles provides continuous, antibiotic free antibacterial activity. In a mouse MRSA infected wound model, this hydrogel achieves complete closure within 14 days with improved tissue regeneration. By integrating ion mediated antibacterial action, photothermal bacterial inactivation, and active mechanical contraction in a single platform, this design addresses the intertwined challenges of infection and impaired closure without the compromises of conventional approaches.
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BibTeX
@article{hu2026nirtriggered,
title = {{NIR-triggered gelatin-based hydrogel for ion-mechanical synergistic antibacterial therapy and infected wound closure.}},
author = {Xiaoxiao Hu and Lemin Zhang and Ruixin Hao and Zeyu Wang and Qiuhong Zhang and Zhicheng Gao and Wei Yang and Yongping Ma},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra07136h},
url = {https://europepmc.org/article/MED/42898738},
note = {CC BY},
}
RIS
TY - JOUR
TI - NIR-triggered gelatin-based hydrogel for ion-mechanical synergistic antibacterial therapy and infected wound closure.
AU - Xiaoxiao Hu
AU - Lemin Zhang
AU - Ruixin Hao
AU - Zeyu Wang
AU - Qiuhong Zhang
AU - Zhicheng Gao
AU - Wei Yang
AU - Yongping Ma
PY - 2026
DA - 2026/10/19
JO - RSC advances
DO - 10.1039/d6ra07136h
UR - https://europepmc.org/article/MED/42898738
AB - Bacterial infection and impaired wound closure remain the leading causes of refractory cutaneous wound healing disorders, inflicting substantial global morbidity and mortality while exacerbating the crisis of antibacterial resistance. Infected cutaneous wounds present a persistent clinical difficulty, given that bacterial infection and inadequate wound closure exacerbate one another. Here, we constructed a hydrogel platform that integrates antibacterial activity and active wound closure through ion-mechanical coupling. The system combines thermoresponsive, catechol-functionalized network with core-shell nanoparticles consisting of a metal-organic framework shell (MOF) encapsulating a liquid metal core (LM). Under near-infrared (NIR) irradiation, the liquid metal generates heat that triggers network contraction to mechanically close the wound. Simultaneously, sustained release of Zn²⁺ and Ga³⁺ from the nanoparticles provides continuous, antibiotic free antibacterial activity. In a mouse MRSA infected wound model, this hydrogel achieves complete closure within 14 days with improved tissue regeneration. By integrating ion mediated antibacterial action, photothermal bacterial inactivation, and active mechanical contraction in a single platform, this design addresses the intertwined challenges of infection and impaired closure without the compromises of conventional approaches.
SN - 2046-2069
ER -