Histologically Confirmed Brain Metastasis Arising From Giant Cell Tumor of Bone: an Uncommon Entity and a Challenging Condition.
4 affiliations
- 1Department of Medical Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France.
- 2Université de Lorraine, Nancy, France.
- 3Department of Neuro-Oncology, University Hospital (CHU) of Nancy, Nancy, France.
- 4Department of Orthopedic Surgery, University Hospital (CHU) of Nancy, Nancy, France.
Abstract
BACKGROUND Giant cell tumors of bone (GCTBs), while classified as indolent, are characterized by their locally aggressive nature and their ability to form metastases in rare cases, mainly in the lungs. To our knowledge, this case is the third reported case of GCTB central nervous system involvement in the literature. CASE REPORT We report the exceptional case of a 39-year-old patient with no significant medical history who presented with a GCTB of the left distal femur, treated with preoperative denosumab and surgical resection with massive prosthetic reconstruction. Fifteen months later, the onset of tremors and a partial seizure revealed a right parietal brain metastasis, histologically confirmed as a secondary site of GCTB. Management included surgical excision of the brain lesion, followed by close monitoring with brain MRI, without adjuvant radiotherapy. Before the present report, only 2 cases of GCTB metastasis involving the central nervous system have been reported, including an intramedullary thoracic lesion and bilateral parietal lesions. CONCLUSIONS This case is the third reported case of GCTB metastasis with central nervous system involvement, highlighting the importance of prolonged follow-up and an individualized multidisciplinary approach for these tumors, which usually metastasize to the lungs. Although these 3 case reports help to characterize this rare condition of secondary central nervous system involvement in GCTBs, they do not justify routine brain imaging or a set standard for follow-up strategies; instead, a multidisciplinary and individualized approach is recommended. The patient is currently in clinical and radiological remission.
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BibTeX
@article{claessens2026histologically,
title = {{Histologically Confirmed Brain Metastasis Arising From Giant Cell Tumor of Bone: an Uncommon Entity and a Challenging Condition.}},
author = {Arthur Claessens and Sophie Martin and Victoire Thiebaut and Marie-Hélène Maillot Baron and François Sirveaux and Anne Kieffer},
journal = {The American journal of case reports},
year = {2026},
month = oct,
doi = {10.12659/ajcr.953858},
url = {https://europepmc.org/article/MED/42844792},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Histologically Confirmed Brain Metastasis Arising From Giant Cell Tumor of Bone: an Uncommon Entity and a Challenging Condition.
AU - Arthur Claessens
AU - Sophie Martin
AU - Victoire Thiebaut
AU - Marie-Hélène Maillot Baron
AU - François Sirveaux
AU - Anne Kieffer
PY - 2026
DA - 2026/10/08
JO - The American journal of case reports
DO - 10.12659/ajcr.953858
UR - https://europepmc.org/article/MED/42844792
AB - BACKGROUND Giant cell tumors of bone (GCTBs), while classified as indolent, are characterized by their locally aggressive nature and their ability to form metastases in rare cases, mainly in the lungs. To our knowledge, this case is the third reported case of GCTB central nervous system involvement in the literature. CASE REPORT We report the exceptional case of a 39-year-old patient with no significant medical history who presented with a GCTB of the left distal femur, treated with preoperative denosumab and surgical resection with massive prosthetic reconstruction. Fifteen months later, the onset of tremors and a partial seizure revealed a right parietal brain metastasis, histologically confirmed as a secondary site of GCTB. Management included surgical excision of the brain lesion, followed by close monitoring with brain MRI, without adjuvant radiotherapy. Before the present report, only 2 cases of GCTB metastasis involving the central nervous system have been reported, including an intramedullary thoracic lesion and bilateral parietal lesions. CONCLUSIONS This case is the third reported case of GCTB metastasis with central nervous system involvement, highlighting the importance of prolonged follow-up and an individualized multidisciplinary approach for these tumors, which usually metastasize to the lungs. Although these 3 case reports help to characterize this rare condition of secondary central nervous system involvement in GCTBs, they do not justify routine brain imaging or a set standard for follow-up strategies; instead, a multidisciplinary and individualized approach is recommended. The patient is currently in clinical and radiological remission.
SN - 1941-5923
ER -