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Peer-reviewedCC BY 4.0Biomolecules

Bile Acids and Their Receptors in Respiratory Diseases: Mechanistic and Therapeutic Perspectives

  • Juanjuan Wan1,2
  • Hui Zong1
  • Dongdong He1
  • Dingtao Li1
  • Jing Yu1
  • Guodong Wang1
  • Liting Liu1
  • Chuansheng Huang2
  • Xinchun Wang2
  • Liping Wang1
  1. 1School of Pharmacy, Shihezi University, Shihezi 832002, China
  2. 2Department of Pharmacy, First Affiliated Hospital, Shihezi University, Shihezi 832008, China
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Abstract

Animal bile has been used for millennia in traditional Chinese medicine as a cough suppressant and bronchodilator. As the primary functional constituents of bile, bile acids (BAs) are believed to mediate these physiological effects. Although the role of BAs in enterohepatic circulation is well-characterized, and recent advances have highlighted their immunomodulatory functions, their pathophysiological significance in the respiratory system has been largely overlooked. This review synthesizes emerging evidence on the multidimensional roles of BAs and their receptor-mediated signaling pathways, with a focus on their contribution to the pathogenesis of major respiratory diseases such as asthma, pulmonary fibrosis, and lung injury.

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Cite

BibTeXRIS
BibTeX
@article{wan2026bile,
  title = {{Bile Acids and Their Receptors in Respiratory Diseases: Mechanistic and Therapeutic Perspectives}},
  author = {Juanjuan Wan and Hui Zong and Dongdong He and Dingtao Li and Jing Yu and Guodong Wang and Liting Liu and Chuansheng Huang and Xinchun Wang and Liping Wang},
  journal = {Biomolecules},
  year = {2026},
  month = oct,
  doi = {10.3390/biom16101497},
  url = {https://www.mdpi.com/2218-273X/16/10/1497},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Bile Acids and Their Receptors in Respiratory Diseases: Mechanistic and Therapeutic Perspectives
AU  - Juanjuan Wan
AU  - Hui Zong
AU  - Dongdong He
AU  - Dingtao Li
AU  - Jing Yu
AU  - Guodong Wang
AU  - Liting Liu
AU  - Chuansheng Huang
AU  - Xinchun Wang
AU  - Liping Wang
PY  - 2026
DA  - 2026/10/01
JO  - Biomolecules
DO  - 10.3390/biom16101497
UR  - https://www.mdpi.com/2218-273X/16/10/1497
AB  - Animal bile has been used for millennia in traditional Chinese medicine as a cough suppressant and bronchodilator. As the primary functional constituents of bile, bile acids (BAs) are believed to mediate these physiological effects. Although the role of BAs in enterohepatic circulation is well-characterized, and recent advances have highlighted their immunomodulatory functions, their pathophysiological significance in the respiratory system has been largely overlooked. This review synthesizes emerging evidence on the multidimensional roles of BAs and their receptor-mediated signaling pathways, with a focus on their contribution to the pathogenesis of major respiratory diseases such as asthma, pulmonary fibrosis, and lung injury.
SN  - 2218-273X
ER  -