Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 56 min ago
Peer-reviewedCC BY-NC-NDCell communication and signaling : CCS

Taurine preserves γδ T cell fitness in triple-negative breast cancer.

  • Haibo Duan1,2
  • Ke Li3
  • Wenhui Yuan4,5
  • Lanhong Pan1
  • Min Su1
  • Qiang Quan6
  • Jianfu Zhao7
  • Peng Li8,9
9 affiliations
  1. 1Department of Oncology, Research Center of Cancer Diagnosis and Therapy, The First Affiliated Hospital, Jinan University, Guangzhou, China.
  2. 2Department of Breast Cancer, The First People's Hospital of Foshan, Foshan, China.
  3. 3Department of Geriatrics, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
  4. 4Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology, Shenzhen, China.
  5. 5The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China.
  6. 6Department of Oncology, Research Center of Cancer Diagnosis and Therapy, The First Affiliated Hospital, Jinan University, Guangzhou, China. [email protected].
  7. 7Department of Oncology, Research Center of Cancer Diagnosis and Therapy, The First Affiliated Hospital, Jinan University, Guangzhou, China. [email protected].
  8. 8Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology, Shenzhen, China. [email protected].
  9. 9The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, China. [email protected].
Read full textPDFDOICite

Abstract

Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options. Here, we identified a marked exhaustion phenotype in peripheral Vγ9Vδ2 (Vδ2) T cells from patients with TNBC, characterized by elevated PD-1 and TIM-3 expression. Untargeted serum metabolomics revealed significantly reduced taurine levels, which were inversely associated with Vδ2 T-cell exhaustion. Bioinformatic analyses further showed that higher expression of the taurine transporter SLC6A6 correlated with enhanced immune infiltration and favorable prognosis in TNBC. Mechanistically, taurine uptake via SLC6A6 alleviated immune exhaustion in Vδ2 T cells and enhanced PLCγ1 phosphorylation, thereby promoting IFN-γ and TNF-α production. In vitro, taurine-treated Vδ2 T cells exhibited enhanced cytotoxicity against TNBC cells. In vivo, taurine supplementation suppressed tumor growth in a γδ T cell-dependent manner. Collectively, these findings identify the taurine-SLC6A6 axis as a key regulator of Vδ2 T-cell function in TNBC and suggest taurine supplementation as a potential strategy to enhance γδ T cell-mediated antitumor immunity.

Related

  1. MIF-mediated intercellular crosstalk drives antigen-presenting-like cancer-associated fibroblast differentiation in triple-negative breast cancer via TGF-β signaling
    Translational cancer researchPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  2. 838 ETV6 rearrangements impair T cell infiltration via activating β-Catenin signaling in triple-negative breast cancer
    Yue Wang, Binfeng Lu, Xiaosong Wang
    Journal for ImmunoTherapy of CancerPeer-reviewedCC BYFull textOncologyDOAJ
  3. The Prognostic Role of Vimentin Expression in Triple‐Negative Breast Cancer: A Retrospective Cohort Study
    Erwin Danil Yulian, Tantri Hellyanti, Karl Heinz Leonhardt Rowika
    Cancer reports (Hoboken, N.J.)Peer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. The Smac mimetic drug Xevinapant sensitizes triple negative breast cancer to radiotherapy-induced cell death in a TNFα dependent manner
    M. D. Faye, J. Lafontaine, P. Wong +1
    bioRxivPreprintAll rights reservedFull textOncologybioRxiv
  5. Editorial Note: In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors
    The PLOS One Editors
    PLOS OnePeer-reviewedCC BY 4.0Full textOncologyPLOS

Cite

BibTeXRIS
BibTeX
@article{duan2026taurine,
  title = {{Taurine preserves γδ T cell fitness in triple-negative breast cancer.}},
  author = {Haibo Duan and Ke Li and Wenhui Yuan and Lanhong Pan and Min Su and Qiang Quan and Jianfu Zhao and Peng Li},
  journal = {Cell communication and signaling : CCS},
  year = {2026},
  month = aug,
  doi = {10.1186/s12964-026-03125-2},
  url = {https://europepmc.org/article/MED/42958404},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Taurine preserves γδ T cell fitness in triple-negative breast cancer.
AU  - Haibo Duan
AU  - Ke Li
AU  - Wenhui Yuan
AU  - Lanhong Pan
AU  - Min Su
AU  - Qiang Quan
AU  - Jianfu Zhao
AU  - Peng Li
PY  - 2026
DA  - 2026/08/01
JO  - Cell communication and signaling : CCS
DO  - 10.1186/s12964-026-03125-2
UR  - https://europepmc.org/article/MED/42958404
AB  - Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options. Here, we identified a marked exhaustion phenotype in peripheral Vγ9Vδ2 (Vδ2) T cells from patients with TNBC, characterized by elevated PD-1 and TIM-3 expression. Untargeted serum metabolomics revealed significantly reduced taurine levels, which were inversely associated with Vδ2 T-cell exhaustion. Bioinformatic analyses further showed that higher expression of the taurine transporter SLC6A6 correlated with enhanced immune infiltration and favorable prognosis in TNBC. Mechanistically, taurine uptake via SLC6A6 alleviated immune exhaustion in Vδ2 T cells and enhanced PLCγ1 phosphorylation, thereby promoting IFN-γ and TNF-α production. In vitro, taurine-treated Vδ2 T cells exhibited enhanced cytotoxicity against TNBC cells. In vivo, taurine supplementation suppressed tumor growth in a γδ T cell-dependent manner. Collectively, these findings identify the taurine-SLC6A6 axis as a key regulator of Vδ2 T-cell function in TNBC and suggest taurine supplementation as a potential strategy to enhance γδ T cell-mediated antitumor immunity.
SN  - 1478-811X
ER  -