Skip to content
DraconiticResearch
Search Sources API
203,948 studies31 sourcesUpdated 32 min ago
Peer-reviewedCC BY 4.0Diabetes & Vascular Disease Research

Carotid arterial stiffness is associated with selective glomerular hypofiltration of middle-sized molecules in type 2 diabetes

  • Agne Laucyte-Cibulskiene1,2
  • Elisabeth Kurien Thomas3
  • Isak Lindberg3
  • Peter M. Nilsson1
  • Anders Christensson1,2
  • Jan Nilsson1
  • Michaela Kozakova4
  • Carmela Morizzo5,6
  • Giuseppe Penno4
  • Monia Garofolo4
  • Carlo Palombo5,6
6 affiliations
  1. 1Department of Clinical Sciences Malmö, Lund University, Malmö, Skåne County, Sweden
  2. 2Department of Nephrology, Skane University Hospital, Malmö, Skåne County, Sweden
  3. 3Faculty of Medicine, Lund University, Lund, Skåne County, Sweden
  4. 4Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
  5. 5Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy
  6. 6University of Pisa and Pisa University Hospital, Cardiology Division, Pisa, Italy
Read full textDOICite

Abstract

Background: Type 2 diabetes (T2D) is a major driver of premature vascular aging. We investigated whether Selective Glomerular Hypofiltration Syndromes (SGHS), expressed as ratios of cystatin C– or β2-microglobulin–based estimated glomerular filtration rate to creatinine-based eGFR (eGFRcys/eGFRcr and eGFRb2M/eGFRcr), are associated with carotid, femoral, or aortic stiffness.

Methods: We studied 144 individuals with T2D recruited from the University Diabetology Unit of Pisa, Italy. Local arterial stiffness was assessed at the carotid and femoral arteries using β stiffness index, Peterson’s elastic modulus (Ep), and local wave speed (WS). Systemic stiffness was evaluated by carotid–femoral pulse wave velocity (cfPWV) and augmentation index (AIx). Kidney function was assessed using eGFRcr, eGFRcys, eGFRb2M, mean eGFR, urinary albumin-to-creatinine ratio (UACR), and eGFR ratios.

Results: A 0.1-unit decrease in eGFRcys/eGFRcr showed a borderline association with higher cfPWV (p=0.087), while age, diabetes duration, UACR, and central pulse pressure were stronger predictors. Lower eGFR ratios were associated with higher carotid WS in unadjusted analyses; after adjustment, eGFRcys/eGFRcr showed a nonsignificant trend (p=0.074). No associations were found with femoral stiffness indices.

Conclusions: SGHS was inversely associated with carotid WS in T2D but not with aortic or femoral stiffness.

Related

  1. Serum Osteopontin Is Associated with Cardio-Ankle Vascular Index-Defined Arterial Stiffness in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study
    Cing-Yu Liang, Jer-Chuan Li, Du-An Wu +1
    Diagnostics (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. Attention-Deficit/Hyperactivity Disorder Is Associated With Lower Rates of Adhesive Capsulitis, Bursitis, Shoulder Stiffness, and Revision Shoulder Arthroscopy After Arthroscopic Rotator Cuff Repair
    Kyle N. Zelenski, Jared Sasaki, Navkiran Bedi +4
    Sports HealthPeer-reviewedLicence not statedFull textSurgery & anaesthesiaPMC
  3. Microbiota-Associated Metabolites as Immunometabolic Regulators of Glomerular Inflammation: Disease-Specific Mechanisms and Therapeutic Opportunities.
    Fanyu Hou, Liuxiao Yang, Wu Liu +4
    Journal of inflammation researchPeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  4. Glomerular diseases associated with multiple myeloma: renal pathology and survival outcomes in a retrospective study at Charles Nicolle Hospital, Tunis, Tunisia.
    Meriam Hajji, Samia Barbouch, Seif Azaiez +5
    The Pan African medical journalPeer-reviewedCC BYFull textGeneral medicineEurope PMCPMC
  5. Estimated Small Dense Low-Density Lipoprotein Cholesterol Is Independently Associated With Arterial Stiffness ― Large Japanese Screening Study ―
    Shuya Shinchi, Yuichi Akasaki, Daisuke Tokutake +6
    Circulation JournalPeer-reviewedCC BY-NC-NDFull textCardiovascular medicineJ-STAGE

Cite

BibTeXRIS
BibTeX
@article{laucytecibulskiene2026carotid,
  title = {{Carotid arterial stiffness is associated with selective glomerular hypofiltration of middle-sized molecules in type 2 diabetes}},
  author = {Agne Laucyte-Cibulskiene and Elisabeth Kurien Thomas and Isak Lindberg and Peter M. Nilsson and Anders Christensson and Jan Nilsson and Michaela Kozakova and Carmela Morizzo and Giuseppe Penno and Monia Garofolo and Carlo Palombo},
  journal = {Diabetes \& Vascular Disease Research},
  year = {2026},
  month = sep,
  doi = {10.1177/14791641261493132},
  url = {https://doi.org/10.1177/14791641261493132},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Carotid arterial stiffness is associated with selective glomerular hypofiltration of middle-sized molecules in type 2 diabetes
AU  - Agne Laucyte-Cibulskiene
AU  - Elisabeth Kurien Thomas
AU  - Isak Lindberg
AU  - Peter M. Nilsson
AU  - Anders Christensson
AU  - Jan Nilsson
AU  - Michaela Kozakova
AU  - Carmela Morizzo
AU  - Giuseppe Penno
AU  - Monia Garofolo
AU  - Carlo Palombo
PY  - 2026
DA  - 2026/09/28
JO  - Diabetes & Vascular Disease Research
DO  - 10.1177/14791641261493132
UR  - https://doi.org/10.1177/14791641261493132
AB  - Background: Type 2 diabetes (T2D) is a major driver of premature vascular aging. We investigated whether Selective Glomerular Hypofiltration Syndromes (SGHS), expressed as ratios of cystatin C– or β2-microglobulin–based estimated glomerular filtration rate to creatinine-based eGFR (eGFRcys/eGFRcr and eGFRb2M/eGFRcr), are associated with carotid, femoral, or aortic stiffness.  Methods: We studied 144 individuals with T2D recruited from the University Diabetology Unit of Pisa, Italy. Local arterial stiffness was assessed at the carotid and femoral arteries using β stiffness index, Peterson’s elastic modulus (Ep), and local wave speed (WS). Systemic stiffness was evaluated by carotid–femoral pulse wave velocity (cfPWV) and augmentation index (AIx). Kidney function was assessed using eGFRcr, eGFRcys, eGFRb2M, mean eGFR, urinary albumin-to-creatinine ratio (UACR), and eGFR ratios.  Results: A 0.1-unit decrease in eGFRcys/eGFRcr showed a borderline association with higher cfPWV (p=0.087), while age, diabetes duration, UACR, and central pulse pressure were stronger predictors. Lower eGFR ratios were associated with higher carotid WS in unadjusted analyses; after adjustment, eGFRcys/eGFRcr showed a nonsignificant trend (p=0.074). No associations were found with femoral stiffness indices.  Conclusions: SGHS was inversely associated with carotid WS in T2D but not with aortic or femoral stiffness.
SN  - 1479-1641
SN  - 1752-8984
ER  -