Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting

@article{odermatt2026cardiac,
  title = {{Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting}},
  author = {Rebekka Odermatt and Luca Koechlin and Pedro Lopez‐Ayala and Emel Kaplan and Lourdes Herraiz Recuenco and Gabrielle Huré and Paolo Bima and Luca Crisanti and Karin Wildi and Òscar Miró and Michael Christ and Dagmar I. Keller and Javier F. Martin‐Sanchez and Beata Morawiec and Nicolas Geigy and Felix Mahfoud and Hector Rodriguez Cetina Biefer and Omer Dzemali and Jasper Boeddinghaus and Ivo Strebel and Christian Mueller and Carlos Spagnuolo and Jonas Glaeser and Thomas Nestelberger and Desiree Wussler and Maria Rubini Gimenez and Tobias Zimmermann and Jude Formambuh and Danielle M. Gualandro and Christian Puelacher and Jeanne du Fay de Lavallaz and Koray Durak and Arnaud Champetier and Julia Reinhardt and Kathrin Meissner and Katharina Rentsch and Andreas Buser and Ksenia Slankamenac and Beatriz López and Gemma Martinez‐Nadal and Esther Rodriguez Adrada and Damian Kawecki and Piotr Muzyk and Beatriz López and Gemma Martinez‐Nadal and Esther Rodriguez Adrada and Joanna Gawinecka and Damian Kawecki and Piotr Muzyk and Eliška Potluková and Stephan Steuer and Angelika Hammerer‐Lercher},
  journal = {Journal of the American Heart Association},
  year = {2026},
  month = oct,
  doi = {10.1161/jaha.126.049244},
  url = {https://www.ahajournals.org/doi/10.1161/JAHA.126.049244},
  note = {CC BY-NC-ND},
}

TY  - JOUR
TI  - Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting
AU  - Rebekka Odermatt
AU  - Luca Koechlin
AU  - Pedro Lopez‐Ayala
AU  - Emel Kaplan
AU  - Lourdes Herraiz Recuenco
AU  - Gabrielle Huré
AU  - Paolo Bima
AU  - Luca Crisanti
AU  - Karin Wildi
AU  - Òscar Miró
AU  - Michael Christ
AU  - Dagmar I. Keller
AU  - Javier F. Martin‐Sanchez
AU  - Beata Morawiec
AU  - Nicolas Geigy
AU  - Felix Mahfoud
AU  - Hector Rodriguez Cetina Biefer
AU  - Omer Dzemali
AU  - Jasper Boeddinghaus
AU  - Ivo Strebel
AU  - Christian Mueller
AU  - Carlos Spagnuolo
AU  - Jonas Glaeser
AU  - Thomas Nestelberger
AU  - Desiree Wussler
AU  - Maria Rubini Gimenez
AU  - Tobias Zimmermann
AU  - Jude Formambuh
AU  - Danielle M. Gualandro
AU  - Christian Puelacher
AU  - Jeanne du Fay de Lavallaz
AU  - Koray Durak
AU  - Arnaud Champetier
AU  - Julia Reinhardt
AU  - Kathrin Meissner
AU  - Katharina Rentsch
AU  - Andreas Buser
AU  - Ksenia Slankamenac
AU  - Beatriz López
AU  - Gemma Martinez‐Nadal
AU  - Esther Rodriguez Adrada
AU  - Damian Kawecki
AU  - Piotr Muzyk
AU  - Beatriz López
AU  - Gemma Martinez‐Nadal
AU  - Esther Rodriguez Adrada
AU  - Joanna Gawinecka
AU  - Damian Kawecki
AU  - Piotr Muzyk
AU  - Eliška Potluková
AU  - Stephan Steuer
AU  - Angelika Hammerer‐Lercher
PY  - 2026
DA  - 2026/10/20
JO  - Journal of the American Heart Association
DO  - 10.1161/jaha.126.049244
UR  - https://www.ahajournals.org/doi/10.1161/JAHA.126.049244
AB  - BACKGROUND: Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high-sensitivity cardiac troponin (hs-cTn). cMyC (cardiac myosin-binding protein C), because of its faster release kinetics and greater abundance, may offer improved diagnostic performance in this population. METHODS: The diagnostic accuracy of cMyC was directly compared with that of hs-cTnT and hs-cTnI in a prospective, international, multicenter, diagnostic study enrolling adult patients presenting to the emergency department with acute chest discomfort. Final diagnoses were centrally adjudicated by 2 independent cardiologists using all available clinical and study-specific data, including imaging and serial hs-cTnT measurements. Patients were stratified according to the presence or absence of prior CABG. RESULTS: <0.001). In the CABG group, the diagnostic accuracy of cMyC as quantified by the area under the curve was 0.88 (95% CI, 0.85-0.92), which was comparable but not superior to that of hs-cTnT (0.89 [95% CI, 0.86-0.92]) and hs-cTnI (0.88 [95% CI, 0.84-0.91]). These findings were consistent across alternative high-sensitivity cMyC assays. CONCLUSIONS: In patients with prior CABG, cMyC demonstrated high diagnostic accuracy for myocardial infarction, but not superior to established hs-cTnT and hs-cTnI assays. REGISTRATION: URL: clinicaltrials.gov; Unique Identifier: NCT00470587.
SN  - 2047-9980
ER  -