Helical Folding of Abiotic Chiral Poly(phosphodiester)s
Abstract
Functions of biomolecules are intimately linked to their structures which result from the folding of a linear sequence of building blocks, amino-acids for proteins and nucleotides for DNA. In the quest to achieve functions with similar efficiency and selectivity that of biomolecules, several synthetic mimics of secondary structures of proteins have been developed but, on the other hand, only scares examples of de novo design of DNA mimics are available. Most of described DNA inspired molecular systems are based on modifications of either the sugar/phosphate backbone or nucleobases. Here are presented the design, the synthesis and the structural characterization of a new class of synthetic phosphodiester oligomers, composed of an aromatic chiral building block, that fold into single helical architectures. Folding pattern diverge from its natural counterpart (DNA) but through intramolecular H-bonds and aromatic stacking these oligomers show similar cooperative temperature dependence stability.
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BibTeX
@article{barman2026helical,
title = {{Helical Folding of Abiotic Chiral Poly(phosphodiester)s}},
author = {Ranajit Barman and Brice Kauffmann and Jean‐françois Lutz and Victor Maurizot},
journal = {Chemistry - A European Journal},
year = {2026},
month = may,
doi = {10.1002/chem.71189},
url = {https://hal.science/hal-05760245v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Helical Folding of Abiotic Chiral Poly(phosphodiester)s
AU - Ranajit Barman
AU - Brice Kauffmann
AU - Jean‐françois Lutz
AU - Victor Maurizot
PY - 2026
DA - 2026/05/28
JO - Chemistry - A European Journal
DO - 10.1002/chem.71189
UR - https://hal.science/hal-05760245v1
AB - Functions of biomolecules are intimately linked to their structures which result from the folding of a linear sequence of building blocks, amino-acids for proteins and nucleotides for DNA. In the quest to achieve functions with similar efficiency and selectivity that of biomolecules, several synthetic mimics of secondary structures of proteins have been developed but, on the other hand, only scares examples of de novo design of DNA mimics are available. Most of described DNA inspired molecular systems are based on modifications of either the sugar/phosphate backbone or nucleobases. Here are presented the design, the synthesis and the structural characterization of a new class of synthetic phosphodiester oligomers, composed of an aromatic chiral building block, that fold into single helical architectures. Folding pattern diverge from its natural counterpart (DNA) but through intramolecular H-bonds and aromatic stacking these oligomers show similar cooperative temperature dependence stability.
SN - 0947-6539
SN - 1521-3765
ER -