Acute Promyelocytic Leukemia with t(11;17)(q23.2;q21.2) Treated with Haploidentical Transplantation Using Post-transplant Cyclophosphamide
Abstract
The majority of acute promyelocytic leukemia (APL) cases have t(15;17)(q24.1;q21.2), but there are rare cases with other chromosomal translocations. These atypical APLs have different morphologies and prognoses than typical APL. We herein report the case of a 55-year-old man with APL and t(11;17)(q23.2;q21.2). The patient was diagnosed with APL based on its distinctive morphology. Later, t(11;17)(q23.2;q21.2) was detected, thus suggesting the presence of the ZBTB16::RARA fusion gene. He underwent haploidentical transplantation using post-transplant cyclophosphamide after conventional chemotherapy and maintained long-term remission. This case highlights the importance of a morphological diagnosis and allogeneic hematopoietic stem cell transplantation in APL with t(11;17)(q23.2;q21.2).
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BibTeX
@article{ito2026acute,
title = {{Acute Promyelocytic Leukemia with t(11;17)(q23.2;q21.2) Treated with Haploidentical Transplantation Using Post-transplant Cyclophosphamide}},
author = {Yujiro Ito and Ayato Sumioka and Ibuki Takatsuka and Kazuyuki Shigeno and Kensuke Naito},
journal = {Internal Medicine},
year = {2026},
month = oct,
doi = {10.2169/internalmedicine.6797-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6797-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Acute Promyelocytic Leukemia with t(11;17)(q23.2;q21.2) Treated with Haploidentical Transplantation Using Post-transplant Cyclophosphamide
AU - Yujiro Ito
AU - Ayato Sumioka
AU - Ibuki Takatsuka
AU - Kazuyuki Shigeno
AU - Kensuke Naito
PY - 2026
DA - 2026/10/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.6797-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6797-25/_article
AB - The majority of acute promyelocytic leukemia (APL) cases have t(15;17)(q24.1;q21.2), but there are rare cases with other chromosomal translocations. These atypical APLs have different morphologies and prognoses than typical APL. We herein report the case of a 55-year-old man with APL and t(11;17)(q23.2;q21.2). The patient was diagnosed with APL based on its distinctive morphology. Later, t(11;17)(q23.2;q21.2) was detected, thus suggesting the presence of the ZBTB16::RARA fusion gene. He underwent haploidentical transplantation using post-transplant cyclophosphamide after conventional chemotherapy and maintained long-term remission. This case highlights the importance of a morphological diagnosis and allogeneic hematopoietic stem cell transplantation in APL with t(11;17)(q23.2;q21.2).
SN - 1349-7235
SN - 0918-2918
ER -