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PreprintCC BYbioRxiv

Proliferation and mutation as humoral immune response

  • I. Meilijson1
  • L. L. Sacerdote
  1. 1Tel Aviv University
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Abstract

The affinity maturation process, through which antibodies acquire relatively high affinity for an invading pathogen, involves complex mechanisms whose relative importance is not yet fully understood. This study proposes an analytical model of this process, to investigate the main factors governing proliferation and mutation and assess their respective roles. The model suggests that the immune system should not be expected to follow a single, rigid evolutionary pattern, as a wide range of proliferation and mutation strategies can yield nearly optimal outcomes. Keywords: Antibody, antigen, affinity, B-cell, mutation, proliferation

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Cite

BibTeXRIS
BibTeX
@misc{meilijson2026proliferation,
  title = {{Proliferation and mutation as humoral immune response}},
  author = {I. Meilijson and L. L. Sacerdote},
  howpublished = {bioRxiv},
  year = {2026},
  month = nov,
  doi = {10.64898/2026.11.06.764896},
  url = {https://www.biorxiv.org/content/10.64898/2026.11.06.764896v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Proliferation and mutation as humoral immune response
AU  - I. Meilijson
AU  - L. L. Sacerdote
PY  - 2026
DA  - 2026/11/06
PB  - bioRxiv
DO  - 10.64898/2026.11.06.764896
UR  - https://www.biorxiv.org/content/10.64898/2026.11.06.764896v1
AB  - The affinity maturation process, through which antibodies acquire relatively high affinity for an invading pathogen, involves complex mechanisms whose relative importance is not yet fully understood. This study proposes an analytical model of this process, to investigate the main factors governing proliferation and mutation and assess their respective roles. The model suggests that the immune system should not be expected to follow a single, rigid evolutionary pattern, as a wide range of proliferation and mutation strategies can yield nearly optimal outcomes. Keywords: Antibody, antigen, affinity, B-cell, mutation, proliferation
ER  -