CD20-Positive B-Cell Non-Hodgkin Lymphoma Associated With Recurrent Acute Pancreatitis, Bilateral Renal Lesions, and Retroperitoneal Lymphadenopathy.
- 1Internal Medicine, Palmetto General Hospital, Miami, USA.
- 2Internal Medicine, American University of the Caribbean School of Medicine, Miami, USA.
Abstract
Acute pancreatitis is most often caused by gallstones, alcohol use, or hypertriglyceridemia, whereas malignancy is an uncommon association. We report a case of a 29-year-old woman with recurrent acute pancreatitis without a clearly dominant, identifiable cause. Although she reported intermittent heavy weekend alcohol use, recurrence after initial improvement, increasing lactate dehydrogenase (LDH), bilateral renal cortical lesions, and progressive retroperitoneal lymphadenopathy suggested a systemic process. Core biopsy of a retroperitoneal lymph node demonstrated a CD20-positive B-cell non-Hodgkin lymphoma with a Ki-67 proliferation index of up to 80%. Limited tissue and nondiagnostic flow cytometry prevented definitive subclassification; diffuse large B-cell lymphoma (DLBCL) remained in the differential diagnosis. One documented cycle of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was administered during a subsequent hospitalization, with short-term symptomatic, pancreatic enzyme, and renal improvement. The patient was subsequently lost to follow-up. This case emphasizes the importance of considering lymphoproliferative disease when recurrent pancreatitis is accompanied by progressive systemic imaging abnormalities.
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BibTeX
@article{sarfraz2026cd20positive,
title = {{CD20-Positive B-Cell Non-Hodgkin Lymphoma Associated With Recurrent Acute Pancreatitis, Bilateral Renal Lesions, and Retroperitoneal Lymphadenopathy.}},
author = {Rehan Sarfraz and Magnie L Ledesma Leon and Dunia Nabi and Laura Hernandez Carratala and Jennifer Fuller},
journal = {Cureus},
year = {2026},
month = sep,
doi = {10.7759/cureus.116919},
url = {https://europepmc.org/article/MED/42928836},
note = {CC BY},
}
RIS
TY - JOUR
TI - CD20-Positive B-Cell Non-Hodgkin Lymphoma Associated With Recurrent Acute Pancreatitis, Bilateral Renal Lesions, and Retroperitoneal Lymphadenopathy.
AU - Rehan Sarfraz
AU - Magnie L Ledesma Leon
AU - Dunia Nabi
AU - Laura Hernandez Carratala
AU - Jennifer Fuller
PY - 2026
DA - 2026/09/25
JO - Cureus
DO - 10.7759/cureus.116919
UR - https://europepmc.org/article/MED/42928836
AB - Acute pancreatitis is most often caused by gallstones, alcohol use, or hypertriglyceridemia, whereas malignancy is an uncommon association. We report a case of a 29-year-old woman with recurrent acute pancreatitis without a clearly dominant, identifiable cause. Although she reported intermittent heavy weekend alcohol use, recurrence after initial improvement, increasing lactate dehydrogenase (LDH), bilateral renal cortical lesions, and progressive retroperitoneal lymphadenopathy suggested a systemic process. Core biopsy of a retroperitoneal lymph node demonstrated a CD20-positive B-cell non-Hodgkin lymphoma with a Ki-67 proliferation index of up to 80%. Limited tissue and nondiagnostic flow cytometry prevented definitive subclassification; diffuse large B-cell lymphoma (DLBCL) remained in the differential diagnosis. One documented cycle of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was administered during a subsequent hospitalization, with short-term symptomatic, pancreatic enzyme, and renal improvement. The patient was subsequently lost to follow-up. This case emphasizes the importance of considering lymphoproliferative disease when recurrent pancreatitis is accompanied by progressive systemic imaging abnormalities.
SN - 2168-8184
ER -