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Peer-reviewedCC BY-NC-ND 4.0Reproductive Health

Chance of live birth in women with recurrent pregnancy loss referred to a French assisted reproductive technology center

  • Sarah Derradj1
  • Albane Vandecandelaere2
  • Pierre Loiseau3
  • Dorian Bosquet2
  • Rosalie Cabry2,4
  • Amandine Dernoncourt3,5,6
6 affiliations
  1. 1Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire Amiens-Picardie, Université Picardie Jules Verne, Amiens, France
  2. 2Service de Médecine et biologie de la reproduction, Centres d’Étude et de Conservation des Œufs et du Sperme (CECOS), Centre Hospitalier Universitaire Amiens-Picardie, Université Picardie Jules Verne, Amiens, France
  3. 3Service de Médecine interne et Réseau d’Epidémiologie Clinique International Francophone (RECIF), Centre Hospitalier Universitaire Amiens-Picardie, Université Picardie Jules Verne, Amiens, France
  4. 4PERITOX-(UMR-I 01), UPJV/INERIS, UPJV, CURS, Chemin du Thil, Amiens, F-80025 France
  5. 5Equipe ECAMO, Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004 France
  6. 6Centre Hospitalo-Universitaire Amiens-Picardie, Service de Médecine interne, Université Picardie Jules Verne, Réseau d’Epidémiologie Clinique International Francophone, Amiens, France
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Abstract

Background: Recurrent pregnancy loss (RPL) is a multifactorial condition, with over 50% of cases remaining unexplained. The absence of therapeutic consensus raises questions regarding referral for assisted reproductive technology (ART).

Objective: To evaluate live birth rates and predictors of success among women with RPL referred to a tertiary ART center.

Methods: We conducted a retrospective cohort study. Women aged 18–42 years with ≥ 3 pregnancy losses before 14 weeks’ gestation, referred to the ART center of Amiens-Picardie University Hospital (2014–2022) were included. The primary outcome was achieving a live birth during follow-up. Independent predictors were identified using stepwise logistic regression.

Results: Among the 85 women with RPL included (median age 29.6 [8.6] years), 49/85 (57.6%) had no underlying infertility issues, and 36/85 (42.3%) had associated infertility issues. Most women were nulliparous (50/85, 58.8%), and had a median of 3 [1] previous miscarriages. Overall, 64/85 (75.3%) achieved at least one live birth: 33/64 (52%) spontaneously and 31/64 (48%) via ART, with median times to conception of 13.6 [10.5] and 14.2 [10.6] months, respectively. ART use was more frequent among infertile women (≥1 IVF/ICSI cycle: 26/36, 72.2% vs. 17/49, 34.7%; p = 0.001), leading to a higher proportion of medically-assisted conceptions in this group (20/24, 83.3% vs. 11/40, 27.5%; p < 0.001). Diminished ovarian reserve and a higher number of previous miscarriages were independently associated with lower live birth rates (aOR 0.26 [0.08–0.89] and 0.76 [0.53–0.96], respectively).

Conclusion: Approximately three-quarters of women with RPL achieved a live birth, most after spontaneous conception. ART should be reserved for couples with confirmed infertility or when another underlying cause clearly justifies intervention.

Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12978-026-02433-7.

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Cite

BibTeXRIS
BibTeX
@article{derradj2026chance,
  title = {{Chance of live birth in women with recurrent pregnancy loss referred to a French assisted reproductive technology center}},
  author = {Sarah Derradj and Albane Vandecandelaere and Pierre Loiseau and Dorian Bosquet and Rosalie Cabry and Amandine Dernoncourt},
  journal = {Reproductive Health},
  year = {2026},
  month = aug,
  doi = {10.1186/s12978-026-02433-7},
  url = {https://doi.org/10.1186/s12978-026-02433-7},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Chance of live birth in women with recurrent pregnancy loss referred to a French assisted reproductive technology center
AU  - Sarah Derradj
AU  - Albane Vandecandelaere
AU  - Pierre Loiseau
AU  - Dorian Bosquet
AU  - Rosalie Cabry
AU  - Amandine Dernoncourt
PY  - 2026
DA  - 2026/08/08
JO  - Reproductive Health
DO  - 10.1186/s12978-026-02433-7
UR  - https://doi.org/10.1186/s12978-026-02433-7
AB  - Background: Recurrent pregnancy loss (RPL) is a multifactorial condition, with over 50% of cases remaining unexplained. The absence of therapeutic consensus raises questions regarding referral for assisted reproductive technology (ART).  Objective: To evaluate live birth rates and predictors of success among women with RPL referred to a tertiary ART center.  Methods: We conducted a retrospective cohort study. Women aged 18–42 years with ≥ 3 pregnancy losses before 14 weeks’ gestation, referred to the ART center of Amiens-Picardie University Hospital (2014–2022) were included. The primary outcome was achieving a live birth during follow-up. Independent predictors were identified using stepwise logistic regression.  Results: Among the 85 women with RPL included (median age 29.6 [8.6] years), 49/85 (57.6%) had no underlying infertility issues, and 36/85 (42.3%) had associated infertility issues. Most women were nulliparous (50/85, 58.8%), and had a median of 3 [1] previous miscarriages. Overall, 64/85 (75.3%) achieved at least one live birth: 33/64 (52%) spontaneously and 31/64 (48%) via ART, with median times to conception of 13.6 [10.5] and 14.2 [10.6] months, respectively. ART use was more frequent among infertile women (≥1 IVF/ICSI cycle: 26/36, 72.2% vs. 17/49, 34.7%; p = 0.001), leading to a higher proportion of medically-assisted conceptions in this group (20/24, 83.3% vs. 11/40, 27.5%; p < 0.001). Diminished ovarian reserve and a higher number of previous miscarriages were independently associated with lower live birth rates (aOR 0.26 [0.08–0.89] and 0.76 [0.53–0.96], respectively).  Conclusion: Approximately three-quarters of women with RPL achieved a live birth, most after spontaneous conception. ART should be reserved for couples with confirmed infertility or when another underlying cause clearly justifies intervention.  Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12978-026-02433-7.
SN  - 1742-4755
ER  -