From the skin to the thyroid: immunological mechanisms and therapeutic implications of the comorbidity between chronic spontaneous urticaria and autoimmune thyroid disease
4 affiliations
- 1Guang dong Provincial Hospital of Chinese Medicine, Guizhou Hospital
- 2The Traditional Chinese Medicine Hospital Of Longquanyi
- 3SCATCM Key Laboratory of Traditional Chinese Medicine Health Products Research andClinical Evaluation (Yibin Traditional Chinese Medicine Hospital); Yibin Clinical Research Center for Traditional Chinese Medicine Health Products
- 4Department of Dermatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University
Abstract
Chronic spontaneous urticaria (CSU) is the most common subtype of chronic urticaria, characterized by recurrent wheals and pruritus without identifiable triggers. CSU is a complex autoimmune skin disease, and patients with type I and type IIb autoimmune subtypes frequently have comorbid autoimmune thyroid diseases (AITD), such as Hashimoto’s thyroiditis (HT), suggesting shared immunological mechanisms between the two conditions. This article systematically reviews the epidemiological characteristics, multidimensional pathogenesis, and advances in clinical diagnosis and treatment strategies for CSU–AITD comorbidity. We focus on the roles of thyroid autoantibodies, immunoglobulin E (IgE)-mediated immune responses, and the complement system in disease progression, highlight the controversial mechanisms linking the two conditions and their therapeutic implications, summarize current treatment strategies targeting the comorbidity, and explore whether thyroid antibodies represent a causative factor or merely an epiphenomenon.
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BibTeX
@article{chen2026from,
title = {{From the skin to the thyroid: immunological mechanisms and therapeutic implications of the comorbidity between chronic spontaneous urticaria and autoimmune thyroid disease}},
author = {Qianqian Chen and Ting Yang and Xiaodan Hu and Rukang Chen},
journal = {Frontiers in Immunology},
year = {2026},
month = oct,
doi = {10.3389/fimmu.2026.1916978},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1916978/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - From the skin to the thyroid: immunological mechanisms and therapeutic implications of the comorbidity between chronic spontaneous urticaria and autoimmune thyroid disease
AU - Qianqian Chen
AU - Ting Yang
AU - Xiaodan Hu
AU - Rukang Chen
PY - 2026
DA - 2026/10/27
JO - Frontiers in Immunology
DO - 10.3389/fimmu.2026.1916978
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1916978/full
AB - Chronic spontaneous urticaria (CSU) is the most common subtype of chronic urticaria, characterized by recurrent wheals and pruritus without identifiable triggers. CSU is a complex autoimmune skin disease, and patients with type I and type IIb autoimmune subtypes frequently have comorbid autoimmune thyroid diseases (AITD), such as Hashimoto’s thyroiditis (HT), suggesting shared immunological mechanisms between the two conditions. This article systematically reviews the epidemiological characteristics, multidimensional pathogenesis, and advances in clinical diagnosis and treatment strategies for CSU–AITD comorbidity. We focus on the roles of thyroid autoantibodies, immunoglobulin E (IgE)-mediated immune responses, and the complement system in disease progression, highlight the controversial mechanisms linking the two conditions and their therapeutic implications, summarize current treatment strategies targeting the comorbidity, and explore whether thyroid antibodies represent a causative factor or merely an epiphenomenon.
SN - 1664-3224
ER -