Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 27 min ago
Peer-reviewedCC BYmicroPublication Biology

Hedgehog-related gene wrt-10 mediates intergenerational effects of fasting on larval size in Caenorhabditis elegans

  • Saige K. Motkoski1
  • Emma Rossander1
  • Maxwell Schweigel1
  • Muskan Karmani1
  • Nicole M. Templeman1
  1. 1Biology, University of Victoria, Victoria, BC, Canada
Read full textDOICite

Abstract

Low food availability can cause delays in reproductive aging to allow for eventual improvements in conditions, or might promote investment in offspring to increase their survival. Here, we tested whether Caenorhabditis elegans Hedgehog-related wrt-10 mediates these responses. We found that reproductively aged wild-type worms and wrt-10(aus36) null mutants both had a greater likelihood of progeny production after 24-h or 48-h fasting periods in early adulthood, indicating that wrt-10 is not required for this response. However, unlike wild-type, wrt-10(aus36) mutants did not produce longer larvae after fasting. Therefore, wrt-10 may enable diet-restricted C. elegans adults to channel resources towards their progeny.

Related

  1. Integrated Multiomics Reveals Intergenerational Brain Sensory System Remodeling Induced by Parental Intermittent Fasting
    X. Peng, V. J. Lim, Y. Fan +15
    bioRxivPreprintAll rights reservedFull textGenetics & genomicsbioRxiv
  2. Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans.
    J. D. Cohen, K. C. Q. Nguyen, D. H. Hall +2
    bioRxivPreprintCC BY-NDFull textImmunologybioRxiv
  3. Exosome secretion is required for Sonic Hedgehog dispersal and signal gradient formation in the embryonic limb bud mesenchyme
    Sean Corcoran, Joshua Fisher, Timothy A. Sanders +1
    Cell ReportsPeer-reviewedCC BY-NC-ND 4.0General biologyCrossref
  4. Lower Circulating Hedgehog Interacting Protein Levels are Associated With Earlier COPD Onset
    Zakaria Lahmar, Engi Ahmed, Aurélie Fort +5
    Archivos de bronconeumologíaPeer-reviewedCC BY 4.0Full textGeneral biologyHAL
  5. Endosulfan rewires GSK3β to disrupt primary cilia-dependent Hedgehog signalling
    R. Piyush, H. Barmola, A. Bhattacharjya +7
    bioRxivPreprintAll rights reservedFull textCell biologybioRxiv

Cite

BibTeXRIS
BibTeX
@article{motkoski2026hedgehogrelated,
  title = {{Hedgehog-related gene wrt-10 mediates intergenerational effects of fasting on larval size in Caenorhabditis elegans}},
  author = {Saige K. Motkoski and Emma Rossander and Maxwell Schweigel and Muskan Karmani and Nicole M. Templeman},
  journal = {microPublication Biology},
  year = {2026},
  month = aug,
  doi = {10.17912/micropub.biology.002269},
  url = {https://doi.org/10.17912/micropub.biology.002269},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Hedgehog-related gene wrt-10 mediates intergenerational effects of fasting on larval size in Caenorhabditis elegans
AU  - Saige K. Motkoski
AU  - Emma Rossander
AU  - Maxwell Schweigel
AU  - Muskan Karmani
AU  - Nicole M. Templeman
PY  - 2026
DA  - 2026/08/01
JO  - microPublication Biology
DO  - 10.17912/micropub.biology.002269
UR  - https://doi.org/10.17912/micropub.biology.002269
AB  - Low food availability can cause delays in reproductive aging to allow for eventual improvements in conditions, or might promote investment in offspring to increase their survival. Here, we tested whether Caenorhabditis elegans Hedgehog-related wrt-10 mediates these responses. We found that reproductively aged wild-type worms and wrt-10(aus36) null mutants both had a greater likelihood of progeny production after 24-h or 48-h fasting periods in early adulthood, indicating that wrt-10 is not required for this response. However, unlike wild-type, wrt-10(aus36) mutants did not produce longer larvae after fasting. Therefore, wrt-10 may enable diet-restricted C. elegans adults to channel resources towards their progeny.
SN  - 2578-9430
ER  -