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PreprintCC BYbioRxiv

Simulated microgravity induces aging phenotypes in human organoids

  • W.-C. Mu
  • J. Baechle
  • K. Schneider
  • M. Fuentealba
  • F. Wu
  • M. Manwaring-Mueller
  • N. Bracey
  • A. Chebykin
  • A. Saini
  • J. Park
  • J. Kim
  • D. A. Winer
4 more authors
  • A. I. Gale
  • C. Mason
  • M. M. Davis
  • D. Furman1
  1. 1Buck Institute
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Abstract

Simulated microgravity provides a controlled perturbation for testing how loss of mechanical load affects human tissues. After 24 hours in rotating-wall vessels, neural, cardiac and tonsil organoids developed tissue-specific transcriptional responses that overlapped published spaceflight datasets, accompanied by higher transcriptomic-age estimates in neural and cardiac models, altered cardiac-organoid contraction dynamics and modified tonsil-organoid antiviral gene-expression signatures. These findings establish a multi-organoid framework for studying acute responses to gravitational unloading.

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Cite

BibTeXRIS
BibTeX
@misc{mu2026simulated,
  title = {{Simulated microgravity induces aging phenotypes in human organoids}},
  author = {W.-C. Mu and J. Baechle and K. Schneider and M. Fuentealba and F. Wu and M. Manwaring-Mueller and N. Bracey and A. Chebykin and A. Saini and J. Park and J. Kim and D. A. Winer and A. I. Gale and C. Mason and M. M. Davis and D. Furman},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.30.755771},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.30.755771v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Simulated microgravity induces aging phenotypes in human organoids
AU  - W.-C. Mu
AU  - J. Baechle
AU  - K. Schneider
AU  - M. Fuentealba
AU  - F. Wu
AU  - M. Manwaring-Mueller
AU  - N. Bracey
AU  - A. Chebykin
AU  - A. Saini
AU  - J. Park
AU  - J. Kim
AU  - D. A. Winer
AU  - A. I. Gale
AU  - C. Mason
AU  - M. M. Davis
AU  - D. Furman
PY  - 2026
DA  - 2026/09/30
PB  - bioRxiv
DO  - 10.64898/2026.09.30.755771
UR  - https://www.biorxiv.org/content/10.64898/2026.09.30.755771v1
AB  - Simulated microgravity provides a controlled perturbation for testing how loss of mechanical load affects human tissues. After 24 hours in rotating-wall vessels, neural, cardiac and tonsil organoids developed tissue-specific transcriptional responses that overlapped published spaceflight datasets, accompanied by higher transcriptomic-age estimates in neural and cardiac models, altered cardiac-organoid contraction dynamics and modified tonsil-organoid antiviral gene-expression signatures. These findings establish a multi-organoid framework for studying acute responses to gravitational unloading.
ER  -