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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling

  • Olga Evgenevna Voronko1
  • Vitalia Sergeevna Novikova1
  • Olesya Olegovna Klychkova1
  • Margarita Pavlovna Markina1
  • Arthur Anatolievich Lee1
  • Dmitry Alexandrovich Kashirskikh1
  • Victoria Alexandrovna Khotina1
  • Vagif Ali oglu Gasanov1
  1. 1Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia
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Abstract

This review summarizes current knowledge on the role of human cathelicidin LL-37 in the regulation of apoptosis. LL-37 can modulate programmed cell death pathways, exerting either proapoptotic or antiapoptotic effects depending on various factors, such as cell type and peptide concentration. Data on LL-37 derivatives and their involvement in apoptosis are also discussed. Understanding the molecular mechanisms underlying LL-37 regulation of apoptosis is necessary to expand the therapeutic potential of this peptide in various pathological conditions, including cancer.

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Cite

BibTeXRIS
BibTeX
@article{voronko2026apoptosis,
  title = {{Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling}},
  author = {Olga Evgenevna Voronko and Vitalia Sergeevna Novikova and Olesya Olegovna Klychkova and Margarita Pavlovna Markina and Arthur Anatolievich Lee and Dmitry Alexandrovich Kashirskikh and Victoria Alexandrovna Khotina and Vagif Ali oglu Gasanov},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = sep,
  doi = {10.3390/ijms27188351},
  url = {https://www.mdpi.com/1422-0067/27/18/8351},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling
AU  - Olga Evgenevna Voronko
AU  - Vitalia Sergeevna Novikova
AU  - Olesya Olegovna Klychkova
AU  - Margarita Pavlovna Markina
AU  - Arthur Anatolievich Lee
AU  - Dmitry Alexandrovich Kashirskikh
AU  - Victoria Alexandrovna Khotina
AU  - Vagif Ali oglu Gasanov
PY  - 2026
DA  - 2026/09/19
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27188351
UR  - https://www.mdpi.com/1422-0067/27/18/8351
AB  - This review summarizes current knowledge on the role of human cathelicidin LL-37 in the regulation of apoptosis. LL-37 can modulate programmed cell death pathways, exerting either proapoptotic or antiapoptotic effects depending on various factors, such as cell type and peptide concentration. Data on LL-37 derivatives and their involvement in apoptosis are also discussed. Understanding the molecular mechanisms underlying LL-37 regulation of apoptosis is necessary to expand the therapeutic potential of this peptide in various pathological conditions, including cancer.
SN  - 1422-0067
ER  -