Impact of a mediterranean diet on metabolic and inflammatory biomarkers in psychiatric patients with metabolic syndrome
Abstract
Psychiatric patients with metabolic syndrome are at increased risk of cardiometabolic complications due to chronic inflammation, oxidative stress, and metabolic disturbances. The Mediterranean diet (MD) has demonstrated anti-inflammatory and cardiometabolic benefits, but its effects in this population remain insufficiently explored. To evaluate the effects of the MD on anthropometric measures, lipid profile, inflammatory cytokines, and metabolic biomarkers in psychiatric patients with metabolic syndrome. In this randomized crossover trial, 30 adults (15 males and 15 females) with psychiatric disorders and metabolic syndrome received either a MD or the standard hospital diet (HD) for 8 weeks. Anthropometric measurements, blood pressure, fasting blood glucose (FBG), lipid profile, inflammatory cytokines, and metabolic biomarkers were assessed before and after each intervention. Compared with the HD, the MD significantly reduced body weight, percentage body fat (PBF), visceral fat (VF), blood pressure, FBG, and total cholesterol (TC) ( p ≤ 0.05). Pro-inflammatory cytokines interleukin-1 beta (IL-1β), interleukin-12 (IL-12), and tumor necrosis factor-alpha (TNF-α) decreased, while anti-inflammatory cytokines remained within normal ranges following the MD. Most metabolic hormones remained within reference ranges, although triiodothyronine (T3) and melanocyte-stimulating hormone (MSH) were elevated. An 8-week MD intervention improved body composition, metabolic health, and inflammatory status in psychiatric patients with metabolic syndrome. These findings support the MD as a promising nutritional strategy to reduce cardiometabolic risk in this high-risk population.
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BibTeX
@article{alyousef2026impact,
title = {{Impact of a mediterranean diet on metabolic and inflammatory biomarkers in psychiatric patients with metabolic syndrome}},
author = {Ali Abdullah Alyousef and Pandurangan Subash-Babu and Abu ElGasim A. Yagoub and Ghedeir M. Alshammari and Hessah Alshammari and Mohammed Abdullah Alomar and Adnan Faisal Alameer and Ayman Abdrabalrsool Allaw and Mohammed A. Mohammed},
journal = {Scientific Reports},
year = {2026},
month = oct,
doi = {10.1038/s41598-026-72996-9},
url = {https://www.nature.com/articles/s41598-026-72996-9},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Impact of a mediterranean diet on metabolic and inflammatory biomarkers in psychiatric patients with metabolic syndrome
AU - Ali Abdullah Alyousef
AU - Pandurangan Subash-Babu
AU - Abu ElGasim A. Yagoub
AU - Ghedeir M. Alshammari
AU - Hessah Alshammari
AU - Mohammed Abdullah Alomar
AU - Adnan Faisal Alameer
AU - Ayman Abdrabalrsool Allaw
AU - Mohammed A. Mohammed
PY - 2026
DA - 2026/10/05
JO - Scientific Reports
DO - 10.1038/s41598-026-72996-9
UR - https://www.nature.com/articles/s41598-026-72996-9
AB - Psychiatric patients with metabolic syndrome are at increased risk of cardiometabolic complications due to chronic inflammation, oxidative stress, and metabolic disturbances. The Mediterranean diet (MD) has demonstrated anti-inflammatory and cardiometabolic benefits, but its effects in this population remain insufficiently explored. To evaluate the effects of the MD on anthropometric measures, lipid profile, inflammatory cytokines, and metabolic biomarkers in psychiatric patients with metabolic syndrome. In this randomized crossover trial, 30 adults (15 males and 15 females) with psychiatric disorders and metabolic syndrome received either a MD or the standard hospital diet (HD) for 8 weeks. Anthropometric measurements, blood pressure, fasting blood glucose (FBG), lipid profile, inflammatory cytokines, and metabolic biomarkers were assessed before and after each intervention. Compared with the HD, the MD significantly reduced body weight, percentage body fat (PBF), visceral fat (VF), blood pressure, FBG, and total cholesterol (TC) ( p ≤ 0.05). Pro-inflammatory cytokines interleukin-1 beta (IL-1β), interleukin-12 (IL-12), and tumor necrosis factor-alpha (TNF-α) decreased, while anti-inflammatory cytokines remained within normal ranges following the MD. Most metabolic hormones remained within reference ranges, although triiodothyronine (T3) and melanocyte-stimulating hormone (MSH) were elevated. An 8-week MD intervention improved body composition, metabolic health, and inflammatory status in psychiatric patients with metabolic syndrome. These findings support the MD as a promising nutritional strategy to reduce cardiometabolic risk in this high-risk population.
SN - 2045-2322
ER -