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Peer-reviewedCC BY 4.0Journal of Otolaryngology - Head & Neck Surgery

Congenital Cytomegalovirus Infection as a Cause of Meniere’s Disease in a Young Population: A Case Series

  • Karolina Falkenius-Schmidt1,2
  • Tatjana Tomanovic3,4
  • Luca Verrecchia3,4
  • Johannes Ehinger1,2,5
  • Ulrika Löfkvist3,6
  • Eva Karltorp3,4
6 affiliations
  1. 1Department of Otorhinolaryngology, Head and Neck Surgery, Skåne University Hospital, Lund, Sweden
  2. 2Otorhinolaryngology, Department of Clinical Sciences Lund, Lund University, Sweden
  3. 3Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
  4. 4Medical unit Ear, Nose, Throat, Hearing and Balance, Karolinska University Hospital, Stockholm, Sweden
  5. 5Mitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, Sweden
  6. 6Department of Public Health and Caring Sciences, Uppsala University, Sweden
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Abstract

Importance:: Congenital cytomegalovirus (cCMV) is the most common cause of prenatal infection and the leading infectious cause of sensorineural hearing loss in childhood. Novel data indicate vestibular impairment is common in children with cCMV infection. Associations between endolymphatic hydrops and cCMV infection in humans are under debate, research reports are still scarce.

Objective:: To highlight a potential subgroup of Meniere’s disease in young individuals and to support previous findings of recurrent vestibular impairment in children with cCMV infection.

Design:: A retrospective descriptive study of a clinical case series.

Setting:: Skåne University Hospital, Karolinska University Hospital and Sahlgrenska University Hospital in Sweden.

Participants:: Patients with confirmed cCMV infection who presented with symptoms of Meniere’s disease with onset before the age of 25. Patients were identified during routine clinical evaluations.

Intervention:: Data were collected from performed vestibular testing, hearing evaluations and imaging results. Vestibular function was assessed with caloric testing and the video head impulse test. Data from medical records were supplemented with updated information obtained from medical interviews.

Main Outcome Measures:: cCMV infection with recurrent or newly developed vestibular impairment and sensorineural hearing loss in one or both ears.

Results:: Twelve patients aged 15 to 41 years, with confirmed cCMV infection met the inclusion criteria. Six patients experienced the onset of Meniere’s symptoms between 10 and 12 years of age, 4 patients between 16 and 23 years old, and 2 with hearing loss since childhood, developed Meniere’s disease from 30 years of age.

Conclusion and Relevance:: cCMV infection may represent a distinct subgroup of endolymphatic hydrops and Meniere’s disease in young individuals. These findings highlight the importance of considering cCMV testing in young patients presenting with symptoms of endolymphatic hydrops.

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Cite

BibTeXRIS
BibTeX
@article{falkeniusschmidt2026congenital,
  title = {{Congenital Cytomegalovirus Infection as a Cause of Meniere’s Disease in a Young Population: A Case Series}},
  author = {Karolina Falkenius-Schmidt and Tatjana Tomanovic and Luca Verrecchia and Johannes Ehinger and Ulrika Löfkvist and Eva Karltorp},
  journal = {Journal of Otolaryngology - Head \& Neck Surgery},
  year = {2026},
  month = sep,
  doi = {10.1177/19160216261453902},
  url = {https://doi.org/10.1177/19160216261453902},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Congenital Cytomegalovirus Infection as a Cause of Meniere’s Disease in a Young Population: A Case Series
AU  - Karolina Falkenius-Schmidt
AU  - Tatjana Tomanovic
AU  - Luca Verrecchia
AU  - Johannes Ehinger
AU  - Ulrika Löfkvist
AU  - Eva Karltorp
PY  - 2026
DA  - 2026/09/28
JO  - Journal of Otolaryngology - Head & Neck Surgery
DO  - 10.1177/19160216261453902
UR  - https://doi.org/10.1177/19160216261453902
AB  - Importance:: Congenital cytomegalovirus (cCMV) is the most common cause of prenatal infection and the leading infectious cause of sensorineural hearing loss in childhood. Novel data indicate vestibular impairment is common in children with cCMV infection. Associations between endolymphatic hydrops and cCMV infection in humans are under debate, research reports are still scarce.  Objective:: To highlight a potential subgroup of Meniere’s disease in young individuals and to support previous findings of recurrent vestibular impairment in children with cCMV infection.  Design:: A retrospective descriptive study of a clinical case series.  Setting:: Skåne University Hospital, Karolinska University Hospital and Sahlgrenska University Hospital in Sweden.  Participants:: Patients with confirmed cCMV infection who presented with symptoms of Meniere’s disease with onset before the age of 25. Patients were identified during routine clinical evaluations.  Intervention:: Data were collected from performed vestibular testing, hearing evaluations and imaging results. Vestibular function was assessed with caloric testing and the video head impulse test. Data from medical records were supplemented with updated information obtained from medical interviews.  Main Outcome Measures:: cCMV infection with recurrent or newly developed vestibular impairment and sensorineural hearing loss in one or both ears.  Results:: Twelve patients aged 15 to 41 years, with confirmed cCMV infection met the inclusion criteria. Six patients experienced the onset of Meniere’s symptoms between 10 and 12 years of age, 4 patients between 16 and 23 years old, and 2 with hearing loss since childhood, developed Meniere’s disease from 30 years of age.  Conclusion and Relevance:: cCMV infection may represent a distinct subgroup of endolymphatic hydrops and Meniere’s disease in young individuals. These findings highlight the importance of considering cCMV testing in young patients presenting with symptoms of endolymphatic hydrops.
SN  - 1916-0208
SN  - 1916-0216
ER  -