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Peer-reviewedCC BY-NC-NDOral oncology reports

Programmed cell death ligand 2 (PD-L2) expression is inversely correlated with human papillomavirus status in oropharyngeal squamous cell carcinoma (OPSCC) tumors.

  • Jeff J Johnson1,2
  • Wanrui Wang1,2
  • Zonggao Shi3
  • Annie Roble2
  • Brian Crowley2
  • Madison McFarland2
  • Jing Yang1,2
  • Daniel L Miller4
  • Mark W Lingen5
  • M Sharon Stack1,2
5 affiliations
  1. 1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
  2. 2Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
  3. 3Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  4. 4Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.
  5. 5Department of Pathology, University of Chicago, Chicago, IL, USA.
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Abstract

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) associated with infection by the human papillomavirus (HPV) continues to increase and 71% of OPSCC cases in the United States are HPV+. We have previously performed microRNA profiling of HPV+ vs HPV- OPSCC and identified miR-106b as significantly elevated in HPV + cases (Miller et al., 2015; Am J Path 185:679-92 [1]). MicroRNA target prediction identified the gene PDCD1LG2 as a highly ranked target of miR-106b. This gene corresponds to the protein programmed cell death ligand 2 (PD-L2), a high affinity ligand for the programmed cell death protein 1 (PD-1) receptor on T-cells. The objective of this study was to evaluate PD-L2 expression in a panel of HPV+ and HPV- OPSCC tumors. Using tissues from two distinct patient cohorts, results show significantly lower PD-L2 protein expression levels in HPV+ tumors. These data suggest that future research on regulation of PD-L2 expression in HPV+ OPSCC is warranted.

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Cite

BibTeXRIS
BibTeX
@article{johnson2026programmed,
  title = {{Programmed cell death ligand 2 (PD-L2) expression is inversely correlated with human papillomavirus status in oropharyngeal squamous cell carcinoma (OPSCC) tumors.}},
  author = {Jeff J Johnson and Wanrui Wang and Zonggao Shi and Annie Roble and Brian Crowley and Madison McFarland and Jing Yang and Daniel L Miller and Mark W Lingen and M Sharon Stack},
  journal = {Oral oncology reports},
  year = {2026},
  month = sep,
  doi = {10.1016/j.oor.2026.100800},
  url = {https://europepmc.org/article/MED/42852169},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Programmed cell death ligand 2 (PD-L2) expression is inversely correlated with human papillomavirus status in oropharyngeal squamous cell carcinoma (OPSCC) tumors.
AU  - Jeff J Johnson
AU  - Wanrui Wang
AU  - Zonggao Shi
AU  - Annie Roble
AU  - Brian Crowley
AU  - Madison McFarland
AU  - Jing Yang
AU  - Daniel L Miller
AU  - Mark W Lingen
AU  - M Sharon Stack
PY  - 2026
DA  - 2026/09/04
JO  - Oral oncology reports
DO  - 10.1016/j.oor.2026.100800
UR  - https://europepmc.org/article/MED/42852169
AB  - The incidence of oropharyngeal squamous cell carcinoma (OPSCC) associated with infection by the human papillomavirus (HPV) continues to increase and 71% of OPSCC cases in the United States are HPV+. We have previously performed microRNA profiling of HPV+ vs HPV- OPSCC and identified miR-106b as significantly elevated in HPV + cases (Miller et al., 2015; Am J Path 185:679-92 [1]). MicroRNA target prediction identified the gene PDCD1LG2 as a highly ranked target of miR-106b. This gene corresponds to the protein programmed cell death ligand 2 (PD-L2), a high affinity ligand for the programmed cell death protein 1 (PD-1) receptor on T-cells. The objective of this study was to evaluate PD-L2 expression in a panel of HPV+ and HPV- OPSCC tumors. Using tissues from two distinct patient cohorts, results show significantly lower PD-L2 protein expression levels in HPV+ tumors. These data suggest that future research on regulation of PD-L2 expression in HPV+ OPSCC is warranted.
SN  - 2772-9060
ER  -