GBAviewer: a structural database of GBA1 variants in Parkinson's disease
- 1McGill University
Abstract
Background: GBA1 variants are common risk factors for Parkinson's disease (PD), yet the structural consequences of most variants remain uncharacterized. No centralized resource currently integrates the growing number of GCase structures, compounds, and PD-associated variants. Objectives: To develop an interactive tool mapping GBA1-PD missense variants onto GCase structures, alongside interactors and therapeutic compounds. Methods: We built GBAviewer, an R/Shiny web server integrating GBA1-PD Browser variants with crystal structures, cryo-EM complexes, AlphaFold3 models, and AlphaMissense scores. We also modelled a putative GCase-Saposin C-glucosylceramide ternary complex using AlphaFold3. Results: GBAviewer maps variants in 3D across the GCase active site, LIMP-2 and SapC surfaces, chaperone pockets, and dimerization interface. Our ternary model corroborates SapC binding to the GCase active site entrance, where several variants of unknown significance cluster. Conclusions: GBAviewer is a freely accessible platform for structural analysis of GBA1 variants, supporting mechanistic studies and therapeutic development. Available at: https://g-can.shinyapps.io/GBAviewer/
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BibTeX
@misc{bayne2026gbaviewer,
title = {{GBAviewer: a structural database of GBA1 variants in Parkinson's disease}},
author = {A. N. Bayne and S. C. Parlar and M. G. Shahkhali and L. Chebon-Bore and P. Halder and Z. Gan-Or and J.-F. Trempe},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.05.749596},
url = {https://www.biorxiv.org/content/10.64898/2026.09.05.749596v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - GBAviewer: a structural database of GBA1 variants in Parkinson's disease
AU - A. N. Bayne
AU - S. C. Parlar
AU - M. G. Shahkhali
AU - L. Chebon-Bore
AU - P. Halder
AU - Z. Gan-Or
AU - J.-F. Trempe
PY - 2026
DA - 2026/09/05
PB - bioRxiv
DO - 10.64898/2026.09.05.749596
UR - https://www.biorxiv.org/content/10.64898/2026.09.05.749596v1
AB - Background: GBA1 variants are common risk factors for Parkinson's disease (PD), yet the structural consequences of most variants remain uncharacterized. No centralized resource currently integrates the growing number of GCase structures, compounds, and PD-associated variants. Objectives: To develop an interactive tool mapping GBA1-PD missense variants onto GCase structures, alongside interactors and therapeutic compounds. Methods: We built GBAviewer, an R/Shiny web server integrating GBA1-PD Browser variants with crystal structures, cryo-EM complexes, AlphaFold3 models, and AlphaMissense scores. We also modelled a putative GCase-Saposin C-glucosylceramide ternary complex using AlphaFold3. Results: GBAviewer maps variants in 3D across the GCase active site, LIMP-2 and SapC surfaces, chaperone pockets, and dimerization interface. Our ternary model corroborates SapC binding to the GCase active site entrance, where several variants of unknown significance cluster. Conclusions: GBAviewer is a freely accessible platform for structural analysis of GBA1 variants, supporting mechanistic studies and therapeutic development. Available at: https://g-can.shinyapps.io/GBAviewer/
ER -