Gamma irradiation shapes high value metabolite responses across microbes microalgae and plants
Abstract
Gamma irradiation can function either as an acute physical elicitor that alters redox and metabolic regulation or as a mutagen that generates selectable genetic variation. We compared evidence from bacteria, fungi, microalgae, plants, and plant cell systems using a common framework that links absorbed dose and exposure context to response mode, evidence strength, phenotype stability, and productivity. Across these systems, irradiation can increase metabolite accumulation or support recovery of improved strains and lines, but responses remain strongly dependent on biological material, dosimetry, selection, and cultivation conditions. Heterogeneous dose reporting, inconsistent productivity denominators, limited causal validation, and scarce scale-up data prevent definition of a universal effective dose or mechanism. We therefore distinguish concentration from total yield and volumetric productivity and propose a stage-gated workflow integrating dosimetry, molecular characterization, stability testing, bioprocess evaluation, and safety and economic assessment to support defensible translation.
Related
- Flowering stage shapes the sensory quality and metabolite profile of kiwifruit floral tea
- Mesaconate-Based Polyester Nanoparticles Reveal How Metabolite Isomerism Shapes Polymer Behavior, Macrophage Reprogramming, and Systemic Immunomodulation
- Baseline growth rate shapes pollutant impacts in aquatic environments: Evidence from antibiotic responses in the harmful cyanobacterium Microcystis
- Epithelial NF-κB shapes protective Treg cell responses to restrain intestinal inflammation
- Antagonistic TGR5 and FXR Signaling Shapes STAT1-Dependent Interferon Responses in Intestinal Epithelial Cells
BibTeX
@article{ebadi2026gamma,
title = {{Gamma irradiation shapes high value metabolite responses across microbes microalgae and plants}},
author = {Ali Ebadi and Alireza Neissi and Mostafa Ebadi and Jaber Nasiri and Mojtaba Kordrostami},
journal = {iScience},
year = {2026},
month = oct,
doi = {10.1016/j.isci.2026.117824},
url = {https://www.cell.com/iscience/fulltext/S2589-0042(26)03205-0},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Gamma irradiation shapes high value metabolite responses across microbes microalgae and plants
AU - Ali Ebadi
AU - Alireza Neissi
AU - Mostafa Ebadi
AU - Jaber Nasiri
AU - Mojtaba Kordrostami
PY - 2026
DA - 2026/10/09
JO - iScience
DO - 10.1016/j.isci.2026.117824
UR - https://www.cell.com/iscience/fulltext/S2589-0042(26)03205-0
AB - Gamma irradiation can function either as an acute physical elicitor that alters redox and metabolic regulation or as a mutagen that generates selectable genetic variation. We compared evidence from bacteria, fungi, microalgae, plants, and plant cell systems using a common framework that links absorbed dose and exposure context to response mode, evidence strength, phenotype stability, and productivity. Across these systems, irradiation can increase metabolite accumulation or support recovery of improved strains and lines, but responses remain strongly dependent on biological material, dosimetry, selection, and cultivation conditions. Heterogeneous dose reporting, inconsistent productivity denominators, limited causal validation, and scarce scale-up data prevent definition of a universal effective dose or mechanism. We therefore distinguish concentration from total yield and volumetric productivity and propose a stage-gated workflow integrating dosimetry, molecular characterization, stability testing, bioprocess evaluation, and safety and economic assessment to support defensible translation.
SN - 2589-0042
ER -