Hepatocellular Carcinoma Associated with Hepatic Sarcoidosis and Budd-Chiari Syndrome: A Case Report and…

Abstract

Hepatic sarcoidosis may progress to cirrhosis, whereas Budd-Chiari syndrome (BCS) is characterized by a hepatic venous outflow obstruction and it is associated with the risk of liver injury. The coexistence of hepatic sarcoidosis and BCS is extremely rare, and hepatocellular carcinoma (HCC) has not been previously reported in this setting. We describe the case of a 71-year-old woman with cutaneous sarcoidosis who presented with HCC and was diagnosed with BCS and hepatic granulomas with advanced fibrosis. This case suggests that these two conditions may act additively or synergistically to create a pro-carcinogenic hepatic environment.

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BibTeX RIS

BibTeX

@article{minami2026hepatocellular,
  title = {{Hepatocellular Carcinoma Associated with Hepatic Sarcoidosis and Budd-Chiari Syndrome: A Case Report and Review of the Literature}},
  author = {Yuta Minami and Takanobu Iwadare and Yuma Kamijo and Masahiro Kurozumi and Yoshinori Sato and Mai Iwaya and Takefumi Kimura},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6849-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6849-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Hepatocellular Carcinoma Associated with Hepatic Sarcoidosis and Budd-Chiari Syndrome: A Case Report and Review of the Literature
AU  - Yuta Minami
AU  - Takanobu Iwadare
AU  - Yuma Kamijo
AU  - Masahiro Kurozumi
AU  - Yoshinori Sato
AU  - Mai Iwaya
AU  - Takefumi Kimura
PY  - 2026
DA  - 2026/10/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6849-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6849-25/_article
AB  - Hepatic sarcoidosis may progress to cirrhosis, whereas Budd-Chiari syndrome (BCS) is characterized by a hepatic venous outflow obstruction and it is associated with the risk of liver injury. The coexistence of hepatic sarcoidosis and BCS is extremely rare, and hepatocellular carcinoma (HCC) has not been previously reported in this setting. We describe the case of a 71-year-old woman with cutaneous sarcoidosis who presented with HCC and was diagnosed with BCS and hepatic granulomas with advanced fibrosis. This case suggests that these two conditions may act additively or synergistically to create a pro-carcinogenic hepatic environment.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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