Neural adaptation in Dyslexia: differential patterns for orthography and phonology
4 affiliations
- 1Laboratory of Language Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences
- 2Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw
- 3Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences
- 4Faculty of Psychology, University of Warsaw
Abstract
Dysfunction in neural adaptation to words might be at the core of reading impairment. Children with dyslexia can present difficulties recognizing similarities between repeated linguistic stimuli, as evidenced by a lack of reduced activations (adaptation) in brain regions associated with reading. fMRI Rapid Adaptation (fMRI-RA) provides a sensitive index of the quality of orthographic and phonological representations to some degree independent of the access to those representations. We used fMRI-RA to compare neural adaptation in children (10.01–14.16 y.o.) with dyslexia (DYS; n = 32) and typically reading controls (CON; n = 40). Phonological adaptation was measured in the left temporoparietal cortex (TPC) and orthographic adaptation in the left anterior ventral occipitotemporal cortex (VOT). In TPC, the Group × Condition interaction reached trend level. Planned contrasts, conducted based on a priori hypotheses, were nevertheless consistent with greater phonological selectivity in CON than DYS. Both groups showed comparable orthographic adaptation in VOT. These findings suggest a preserved neural adaptation effect for short, easy, high-frequency words in the VOT in dyslexia group. In sum, reading difficulties may reflect not only single modality deficit but also variations in how orthographic and phonological representations are integrated, highlighting the importance of approaches that examine the interaction between these processes.
Related
- PATIENT-PSYCHOTHERAPIST ADAPTATION PATTERNS: A SYSTEMIC QUALITY OF LIFE ANALYSIS
- Coordinating extreme-heat adaptation at mega-sporting events: early warning and cost sharing in a multi-actor differential game
- Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation
- Genomic co-alteration patterns are associated with differential benefit from first-line third-generation EGFR-TKI plus chemotherapy versus TKI monotherapy in advanced EGFR-mutant NSCLC
- Environmental factors and polygenic risk score for psychiatric and neurodevelopmental disorders in children with dyslexia
BibTeX
@article{wojcik2026neural,
title = {{Neural adaptation in Dyslexia: differential patterns for orthography and phonology}},
author = {M. Wójcik and N. Robak and M. Wypych and M. Dębecka and H. Górecka and K. Jednoróg and A. Dębska},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-60796-0},
url = {https://doi.org/10.1038/s41598-026-60796-0},
note = {CC BY},
}
RIS
TY - JOUR
TI - Neural adaptation in Dyslexia: differential patterns for orthography and phonology
AU - M. Wójcik
AU - N. Robak
AU - M. Wypych
AU - M. Dębecka
AU - H. Górecka
AU - K. Jednoróg
AU - A. Dębska
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-60796-0
UR - https://doi.org/10.1038/s41598-026-60796-0
AB - Dysfunction in neural adaptation to words might be at the core of reading impairment. Children with dyslexia can present difficulties recognizing similarities between repeated linguistic stimuli, as evidenced by a lack of reduced activations (adaptation) in brain regions associated with reading. fMRI Rapid Adaptation (fMRI-RA) provides a sensitive index of the quality of orthographic and phonological representations to some degree independent of the access to those representations. We used fMRI-RA to compare neural adaptation in children (10.01–14.16 y.o.) with dyslexia (DYS; n = 32) and typically reading controls (CON; n = 40). Phonological adaptation was measured in the left temporoparietal cortex (TPC) and orthographic adaptation in the left anterior ventral occipitotemporal cortex (VOT). In TPC, the Group × Condition interaction reached trend level. Planned contrasts, conducted based on a priori hypotheses, were nevertheless consistent with greater phonological selectivity in CON than DYS. Both groups showed comparable orthographic adaptation in VOT. These findings suggest a preserved neural adaptation effect for short, easy, high-frequency words in the VOT in dyslexia group. In sum, reading difficulties may reflect not only single modality deficit but also variations in how orthographic and phonological representations are integrated, highlighting the importance of approaches that examine the interaction between these processes.
SN - 2045-2322
ER -