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Peer-reviewedCC BYMemorias do Instituto Oswaldo Cruz

Blood donation candidates who are deferred in the State of Roraima, Brazilian Amazon: reasons for unsuitability and seroprevalence of transfusion-transmitted pathogens

  • Daniela Ribeiro Roque1,2
  • Fabiana Granja3
  • Filipe Anibal Carvalho-Costa1
  1. 1Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Epidemiologia e Sistemática Molecular, Rio de Janeiro, RJ, Brasil
  2. 2Laboratório Central de Saúde Pública de Roraima, Setor de Imunologia/Parasitologia, Boa Vista, RR, Brasil
  3. 3Universidade Federal de Roraima, Centro de Estudos da Biodiversidade, Laboratório de Biologia Molecular, Boa Vista, RR, Brasil
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Abstract

BACKGROUND: Blood donation candidates who are deferred are not targeted by any health policy.

OBJECTIVES: To describe sociodemographic characteristics of unsuitable blood donation candidates, the causes of unsuitability and compare the prevalence rates of transfusion-transmitted infections in deferred and eligible blood donors.

METHODS: A cross-sectional survey was conducted to obtain sociodemographic data and blood samples; 8,159 blood donation candidates were screened (21.1% rejected, 78.9% approved). A sample of 212 deferred candidates was established.

FINDINGS: Most rejected candidates were female, young adults, with high school or university education, self-declared white, born in the North region and single. Main reasons for unsuitability were low haemoglobin concentration, potential exposure to malaria and risky sexual behaviour. The comparison of seropositivity rates in deferred and eligible blood donation candidates generated the following prevalence ratios (PR) and respective 95% confidence intervals (CI): human immunodeficiency virus (HIV), PR = 6.75 (1.46 - 31.05), p = 0.046; syphilis, PR = 1.47 (0.46 - 4.64), p = 0.463; anti-HBc, PR = 2.84 (1.24 - 6.50); p = 0.023; anti-HCV, PR = 4.67 (1.06 - 20.58), p = 0,080; Chagas disease, PR = 60.75 (5.53 - 667.43), p = 0.003.

MAIN CONCLUSIONS: Treating anaemia in women and controlling malaria in Roraima will reduce the pool of rejected blood donation candidates in the State.

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Cite

BibTeXRIS
BibTeX
@article{roque2026blood,
  title = {{Blood donation candidates who are deferred in the State of Roraima, Brazilian Amazon: reasons for unsuitability and seroprevalence of transfusion-transmitted pathogens}},
  author = {Daniela Ribeiro Roque and Fabiana Granja and Filipe Anibal Carvalho-Costa},
  journal = {Memorias do Instituto Oswaldo Cruz},
  year = {2026},
  month = oct,
  doi = {10.1590/0074-02760250320},
  url = {https://europepmc.org/article/PMC/PMC13722438},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Blood donation candidates who are deferred in the State of Roraima, Brazilian Amazon: reasons for unsuitability and seroprevalence of transfusion-transmitted pathogens
AU  - Daniela Ribeiro Roque
AU  - Fabiana Granja
AU  - Filipe Anibal Carvalho-Costa
PY  - 2026
DA  - 2026/10/30
JO  - Memorias do Instituto Oswaldo Cruz
DO  - 10.1590/0074-02760250320
UR  - https://europepmc.org/article/PMC/PMC13722438
AB  - BACKGROUND: Blood donation candidates who are deferred are not targeted by any health policy.  OBJECTIVES: To describe sociodemographic characteristics of unsuitable blood donation candidates, the causes of unsuitability and compare the prevalence rates of transfusion-transmitted infections in deferred and eligible blood donors.  METHODS: A cross-sectional survey was conducted to obtain sociodemographic data and blood samples; 8,159 blood donation candidates were screened (21.1% rejected, 78.9% approved). A sample of 212 deferred candidates was established.  FINDINGS: Most rejected candidates were female, young adults, with high school or university education, self-declared white, born in the North region and single. Main reasons for unsuitability were low haemoglobin concentration, potential exposure to malaria and risky sexual behaviour. The comparison of seropositivity rates in deferred and eligible blood donation candidates generated the following prevalence ratios (PR) and respective 95% confidence intervals (CI): human immunodeficiency virus (HIV), PR = 6.75 (1.46 - 31.05), p = 0.046; syphilis, PR = 1.47 (0.46 - 4.64), p = 0.463; anti-HBc, PR = 2.84 (1.24 - 6.50); p = 0.023; anti-HCV, PR = 4.67 (1.06 - 20.58), p = 0,080; Chagas disease, PR = 60.75 (5.53 - 667.43), p = 0.003.  MAIN CONCLUSIONS: Treating anaemia in women and controlling malaria in Roraima will reduce the pool of rejected blood donation candidates in the State.
SN  - 0074-0276
SN  - 1678-8060
ER  -