Posterior Cortical Atrophy Phenocopy Associated with Antiphospholipid Syndrome: A Case Report

Abstract

A 37-year-old woman with a history of antiphospholipid syndrome (APS) developed a progressive visuospatial impairment, including difficulty tying shoelaces and inserting keys. A neuropsychological assessment revealed simultagnosia, optic ataxia, dressing apraxia, alexia, agraphia, and left hemispatial neglect, mimicking the symptoms of posterior cortical atrophy (PCA). Brain MRI revealed occipital-parietal atrophy and FLAIR hyperintensities in the watershed areas, suggestive of chronic ischemia. Cerebral blood flow SPECT revealed bilateral hypoperfusion in the same regions. We report that chronic ischemic injury associated with antiphospholipid syndrome can produce a posterior cortical atrophy phenotype.

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BibTeX RIS

BibTeX

@article{nakamura2026posterior,
  title = {{Posterior Cortical Atrophy Phenocopy Associated with Antiphospholipid Syndrome: A Case Report}},
  author = {Jin Nakamura and Yuki Hagiwara and Yoshihiro Furukawa and Kiyoshi Matsukura and Keiichi Hokkoku and Nao Tsutsui and Chiyoko Nagai and Hiroshi Oba and Shunsuke Kobayashi},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.7598-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7598-26/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Posterior Cortical Atrophy Phenocopy Associated with Antiphospholipid Syndrome: A Case Report
AU  - Jin Nakamura
AU  - Yuki Hagiwara
AU  - Yoshihiro Furukawa
AU  - Kiyoshi Matsukura
AU  - Keiichi Hokkoku
AU  - Nao Tsutsui
AU  - Chiyoko Nagai
AU  - Hiroshi Oba
AU  - Shunsuke Kobayashi
PY  - 2026
DA  - 2026/09/08
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7598-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7598-26/_article
AB  - A 37-year-old woman with a history of antiphospholipid syndrome (APS) developed a progressive visuospatial impairment, including difficulty tying shoelaces and inserting keys. A neuropsychological assessment revealed simultagnosia, optic ataxia, dressing apraxia, alexia, agraphia, and left hemispatial neglect, mimicking the symptoms of posterior cortical atrophy (PCA). Brain MRI revealed occipital-parietal atrophy and FLAIR hyperintensities in the watershed areas, suggestive of chronic ischemia. Cerebral blood flow SPECT revealed bilateral hypoperfusion in the same regions. We report that chronic ischemic injury associated with antiphospholipid syndrome can produce a posterior cortical atrophy phenotype.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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