Recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives.
- 1Chemistry Department, Faculty of Science, Cairo University Giza Egypt [email protected] [email protected].
Abstract
Sulfamethoxazole is a clinically important sulfonamide antibiotic that remains a valuable pharmacophore in medicinal chemistry due to its established antibacterial activity and structural versatility. However, the emergence of antimicrobial resistance and limitations related to solubility, pharmacokinetics, and safety have encouraged extensive structural modification of the sulfamethoxazole scaffold. This review summarizes recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives, with emphasis on developments reported during the last five years. Major synthetic approaches discussed include conventional sulfonamide-bond formation, greener synthetic protocols, metal complexation, Schiff base formation, nucleophilic substitution, amidation, cyanoacetylation, chloroacetylation, diazotization, heterocyclic annulation, and hybridization with other pharmacologically active scaffolds. Attention is given to how modification of the aromatic amino group, sulfonamide moiety, and isoxazole ring influences physicochemical properties and biological performance. The review also highlights sulfamethoxazole-based metal complexes, heterocyclic hybrids, prodrug-like derivatives, and nanocarrier-based systems as promising strategies to enhance antimicrobial potency and broaden biological applications, including anticancer, antioxidant, anti-inflammatory, enzyme-inhibitory, and antibiofilm activities. Overall, this review provides an integrated overview of the relationship between synthetic design, structural features, and biological activity, offering useful guidance for the future development of sulfamethoxazole-based therapeutic candidates.
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BibTeX
@article{elwahy2026recent,
title = {{Recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives.}},
author = {Ahmed H M Elwahy and Mohamed R Shaaban and Ismail A Abdelhamid},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra06736k},
url = {https://europepmc.org/article/MED/42909359},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives.
AU - Ahmed H M Elwahy
AU - Mohamed R Shaaban
AU - Ismail A Abdelhamid
PY - 2026
DA - 2026/10/21
JO - RSC advances
DO - 10.1039/d6ra06736k
UR - https://europepmc.org/article/MED/42909359
AB - Sulfamethoxazole is a clinically important sulfonamide antibiotic that remains a valuable pharmacophore in medicinal chemistry due to its established antibacterial activity and structural versatility. However, the emergence of antimicrobial resistance and limitations related to solubility, pharmacokinetics, and safety have encouraged extensive structural modification of the sulfamethoxazole scaffold. This review summarizes recent advances in the synthesis, structural diversification, and biological evaluation of sulfamethoxazole derivatives, with emphasis on developments reported during the last five years. Major synthetic approaches discussed include conventional sulfonamide-bond formation, greener synthetic protocols, metal complexation, Schiff base formation, nucleophilic substitution, amidation, cyanoacetylation, chloroacetylation, diazotization, heterocyclic annulation, and hybridization with other pharmacologically active scaffolds. Attention is given to how modification of the aromatic amino group, sulfonamide moiety, and isoxazole ring influences physicochemical properties and biological performance. The review also highlights sulfamethoxazole-based metal complexes, heterocyclic hybrids, prodrug-like derivatives, and nanocarrier-based systems as promising strategies to enhance antimicrobial potency and broaden biological applications, including anticancer, antioxidant, anti-inflammatory, enzyme-inhibitory, and antibiofilm activities. Overall, this review provides an integrated overview of the relationship between synthetic design, structural features, and biological activity, offering useful guidance for the future development of sulfamethoxazole-based therapeutic candidates.
SN - 2046-2069
ER -