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Peer-reviewedCC BYResuscitation plus

Life satisfaction and self-rated health in long-term survivors after extracorporeal cardiopulmonary resuscitation (ECPR): associations with functional outcome, cognition, anxiety, depression, fatigue, and physical activity

  • Anna Henningsson1
  • Pia Watson1
  • Magnus Segerström2
  • Petra Redfors3
  • Bengt Redfors1
  1. 1Department of Cardiothoracic Anesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden
  2. 2Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Blå Stråket 5, 413 45 Gothenburg, Sweden
  3. 3Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden
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Abstract

Background

The goal of extracorporeal cardiopulmonary resuscitation (ECPR) is not only survival, but long-term satisfaction with life. Whether functional outcome (modified Rankin Scale; mRS), cognition, emotional symptoms, fatigue, and physical activity relate to life satisfaction in ECPR survivors remain unknown. We evaluated these aspects of health and their association with life satisfaction and self-rated health.Methods

This cross-sectional follow-up included survivors ≥1 year after ECPR at Sahlgrenska University Hospital, Gothenburg, Sweden (2010-2021). Primary outcomes were life satisfaction (World Values Survey) and self-rated health (EQ-5D-5L VAS). Secondary outcomes were mRS, Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS), Mental Fatigue Scale (MFS), and self-reported physical activity. Exploratory multivariable linear regression assessed associations with primary outcomes.Results

Of 34 survivors, 26 (76.5%) participated; median follow-up was 5 [IQR 2-7] years; 96% had mRS 0-3. Median life satisfaction was 8 [6-9]/10 and self-rated health 81 [70-90]/100, similar to population reference values (7.55 and 80). Positive screen for cognitive impairment (MoCA < 26) was present in 56%, anxiety (HADS-A ≥ 8) 42%, depression (HADS-D ≥ 8) 15%, and fatigue (MFS ≥ 10.5) 50%. In exploratory multivariable analysis, moderate physical activity was associated with life satisfaction (B 0.36 per day/week; 95% CI 0.06-0.67; p = 0.023) and self-rated health (B 4.60; 0.71-8.50; p = 0.024).Conclusion

Long-term ECPR survivors reported life satisfaction and self-rated health similar to population reference values. In exploratory multivariable analysis, moderate physical activity was the only variable associated with both. This supports assessing life satisfaction and physical activity in post-ECPR follow-up.

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Cite

BibTeXRIS
BibTeX
@article{henningsson2026life,
  title = {{Life satisfaction and self-rated health in long-term survivors after extracorporeal cardiopulmonary resuscitation (ECPR): associations with functional outcome, cognition, anxiety, depression, fatigue, and physical activity}},
  author = {Anna Henningsson and Pia Watson and Magnus Segerström and Petra Redfors and Bengt Redfors},
  journal = {Resuscitation plus},
  year = {2026},
  month = oct,
  doi = {10.1016/j.resplu.2026.101521},
  url = {https://europepmc.org/article/PMC/PMC13717885},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Life satisfaction and self-rated health in long-term survivors after extracorporeal cardiopulmonary resuscitation (ECPR): associations with functional outcome, cognition, anxiety, depression, fatigue, and physical activity
AU  - Anna Henningsson
AU  - Pia Watson
AU  - Magnus Segerström
AU  - Petra Redfors
AU  - Bengt Redfors
PY  - 2026
DA  - 2026/10/07
JO  - Resuscitation plus
DO  - 10.1016/j.resplu.2026.101521
UR  - https://europepmc.org/article/PMC/PMC13717885
AB  - Background  The goal of extracorporeal cardiopulmonary resuscitation (ECPR) is not only survival, but long-term satisfaction with life. Whether functional outcome (modified Rankin Scale; mRS), cognition, emotional symptoms, fatigue, and physical activity relate to life satisfaction in ECPR survivors remain unknown. We evaluated these aspects of health and their association with life satisfaction and self-rated health.Methods  This cross-sectional follow-up included survivors ≥1 year after ECPR at Sahlgrenska University Hospital, Gothenburg, Sweden (2010-2021). Primary outcomes were life satisfaction (World Values Survey) and self-rated health (EQ-5D-5L VAS). Secondary outcomes were mRS, Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS), Mental Fatigue Scale (MFS), and self-reported physical activity. Exploratory multivariable linear regression assessed associations with primary outcomes.Results  Of 34 survivors, 26 (76.5%) participated; median follow-up was 5 [IQR 2-7] years; 96% had mRS 0-3. Median life satisfaction was 8 [6-9]/10 and self-rated health 81 [70-90]/100, similar to population reference values (7.55 and 80). Positive screen for cognitive impairment (MoCA < 26) was present in 56%, anxiety (HADS-A ≥ 8) 42%, depression (HADS-D ≥ 8) 15%, and fatigue (MFS ≥ 10.5) 50%. In exploratory multivariable analysis, moderate physical activity was associated with life satisfaction (B 0.36 per day/week; 95% CI 0.06-0.67; p = 0.023) and self-rated health (B 4.60; 0.71-8.50; p = 0.024).Conclusion  Long-term ECPR survivors reported life satisfaction and self-rated health similar to population reference values. In exploratory multivariable analysis, moderate physical activity was the only variable associated with both. This supports assessing life satisfaction and physical activity in post-ECPR follow-up.
SN  - 2666-5204
ER  -