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Peer-reviewedCC BY-NC-ND 4.0BMC Research Notes

Metabolomic profiling reveals candidate discriminatory metabolites in stable chronic obstructive pulmonary disease and acute exacerbation

  • Yue Zhang1
  • Xinru Liu2
  • Pengyuan Zhuang3
  • Xuejun Guo1
  • Jun Shen3
  1. 1Department of Pulmonary and Critical Care Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092 China
  2. 2Institute of Translational Medicine, Shanghai University, Shanghai, 200444 China
  3. 3Department of Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092 China
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Abstract

Objective: To characterize serum metabolic alterations across healthy controls, stable chronic obstructive pulmonary disease (SCOPD), and acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to explore candidate discriminatory metabolites for COPD-related comparisons.

Results: Serum samples from 19 patients with SCOPD, 20 patients with AECOPD, and 20 non-smoking healthy controls were analyzed by LC-MS/MS-based untargeted metabolomics. COPD groups showed reduced glycerophospholipid and alpha-linolenic acid metabolism compared with controls, whereas AECOPD showed enrichment of unsaturated fatty acid biosynthesis compared with SCOPD. PE(16:1(5Z)/16:1(5Z)) and 14,15-leukotriene C4 showed exploratory discriminatory potential in COPD-versus-control and AECOPD-versus-SCOPD comparisons, respectively. Because the study was small and lacked external validation, these metabolites should be interpreted as hypothesis-generating candidates requiring targeted validation.

Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13104-026-07969-2.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026metabolomic,
  title = {{Metabolomic profiling reveals candidate discriminatory metabolites in stable chronic obstructive pulmonary disease and acute exacerbation}},
  author = {Yue Zhang and Xinru Liu and Pengyuan Zhuang and Xuejun Guo and Jun Shen},
  journal = {BMC Research Notes},
  year = {2026},
  month = aug,
  doi = {10.1186/s13104-026-07969-2},
  url = {https://doi.org/10.1186/s13104-026-07969-2},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Metabolomic profiling reveals candidate discriminatory metabolites in stable chronic obstructive pulmonary disease and acute exacerbation
AU  - Yue Zhang
AU  - Xinru Liu
AU  - Pengyuan Zhuang
AU  - Xuejun Guo
AU  - Jun Shen
PY  - 2026
DA  - 2026/08/08
JO  - BMC Research Notes
DO  - 10.1186/s13104-026-07969-2
UR  - https://doi.org/10.1186/s13104-026-07969-2
AB  - Objective: To characterize serum metabolic alterations across healthy controls, stable chronic obstructive pulmonary disease (SCOPD), and acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to explore candidate discriminatory metabolites for COPD-related comparisons.  Results: Serum samples from 19 patients with SCOPD, 20 patients with AECOPD, and 20 non-smoking healthy controls were analyzed by LC-MS/MS-based untargeted metabolomics. COPD groups showed reduced glycerophospholipid and alpha-linolenic acid metabolism compared with controls, whereas AECOPD showed enrichment of unsaturated fatty acid biosynthesis compared with SCOPD. PE(16:1(5Z)/16:1(5Z)) and 14,15-leukotriene C4 showed exploratory discriminatory potential in COPD-versus-control and AECOPD-versus-SCOPD comparisons, respectively. Because the study was small and lacked external validation, these metabolites should be interpreted as hypothesis-generating candidates requiring targeted validation.  Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13104-026-07969-2.
SN  - 1756-0500
ER  -