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Peer-reviewedCC BYBMC Cancer

Systematic review and meta-analysis of lung metastases incidence in cervical cancer patients

  • Kimia Pakdaman1
  • Amin Esmaeilnia Shirvani1
  • Kasra Pakdaman2
  • Hossein-Ali Nikbakht3
  • Mosua Yeminfroz1
  • Pouyan Ebrahimi4
4 affiliations
  1. 1School of Medicine, Babol University of Medical Sciences
  2. 2School of Nursing and Midwifery, Mazandaran University of Medical Sciences
  3. 3Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences
  4. 4Cancer Research Center, Health Research Institute, Babol University of Medical Sciences
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Abstract

Background Cervical cancer (CC) is a common and aggressive malignancy in women. The lung is its most frequent site of distant metastasis, yet the incidence and risk factors remain underexplored. This study aimed to estimate the incidence of lung metastases (LMs) in CC and characterize their clinical and pathological patterns. Methods We systematically searched PubMed/Medline, Scopus, Embase, Web of Science, and Google Scholar up to May 8, 2025, for studies reporting LMs incidence in CC patients. Eligible studies were assessed using the Joanna Briggs Institute (JBI) tool. Data were analyzed with STATA version 17 using a random-effects model. Pooled estimates were reported with 95% confidence intervals (CIs). Results The global pooled incidence of LMs in CC was 4.31% (95% CI: 3.25–5.37), with the highest regional rate observed in Africa (7.42%). Neuroendocrine carcinoma (NEC) demonstrated the highest histology-specific LMs incidence at 16.91% (95% CI: 11.06–22.76), markedly exceeding adenocarcinoma and squamous cell carcinoma. LMs risk was substantially elevated in advanced stages, rising to 15.75% (95% CI: 4.92–26.58) in stage IV compared to 3.12% (95% CI: 1.74–4.51) in stage I, with an average post-metastasis survival of 32.56 months (95% CI: 7.57–57.54). Conclusion Our results show that the lung is a common site for metastasis in CC, often alongside liver and bone metastases. LMs risk is higher in neuroendocrine carcinoma and advanced stages. These findings can help improve prevention and treatment strategies.

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Cite

BibTeXRIS
BibTeX
@article{pakdaman2026systematic,
  title = {{Systematic review and meta-analysis of lung metastases incidence in cervical cancer patients}},
  author = {Kimia Pakdaman and Amin Esmaeilnia Shirvani and Kasra Pakdaman and Hossein-Ali Nikbakht and Mosua Yeminfroz and Pouyan Ebrahimi},
  journal = {BMC Cancer},
  year = {2026},
  month = jul,
  doi = {10.1186/s12885-026-16579-x},
  url = {https://doi.org/10.1186/s12885-026-16579-x},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Systematic review and meta-analysis of lung metastases incidence in cervical cancer patients
AU  - Kimia Pakdaman
AU  - Amin Esmaeilnia Shirvani
AU  - Kasra Pakdaman
AU  - Hossein-Ali Nikbakht
AU  - Mosua Yeminfroz
AU  - Pouyan Ebrahimi
PY  - 2026
DA  - 2026/07/01
JO  - BMC Cancer
DO  - 10.1186/s12885-026-16579-x
UR  - https://doi.org/10.1186/s12885-026-16579-x
AB  - Background Cervical cancer (CC) is a common and aggressive malignancy in women. The lung is its most frequent site of distant metastasis, yet the incidence and risk factors remain underexplored. This study aimed to estimate the incidence of lung metastases (LMs) in CC and characterize their clinical and pathological patterns. Methods We systematically searched PubMed/Medline, Scopus, Embase, Web of Science, and Google Scholar up to May 8, 2025, for studies reporting LMs incidence in CC patients. Eligible studies were assessed using the Joanna Briggs Institute (JBI) tool. Data were analyzed with STATA version 17 using a random-effects model. Pooled estimates were reported with 95% confidence intervals (CIs). Results The global pooled incidence of LMs in CC was 4.31% (95% CI: 3.25–5.37), with the highest regional rate observed in Africa (7.42%). Neuroendocrine carcinoma (NEC) demonstrated the highest histology-specific LMs incidence at 16.91% (95% CI: 11.06–22.76), markedly exceeding adenocarcinoma and squamous cell carcinoma. LMs risk was substantially elevated in advanced stages, rising to 15.75% (95% CI: 4.92–26.58) in stage IV compared to 3.12% (95% CI: 1.74–4.51) in stage I, with an average post-metastasis survival of 32.56 months (95% CI: 7.57–57.54). Conclusion Our results show that the lung is a common site for metastasis in CC, often alongside liver and bone metastases. LMs risk is higher in neuroendocrine carcinoma and advanced stages. These findings can help improve prevention and treatment strategies.
SN  - 1471-2407
ER  -