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Peer-reviewedLicence not statedOncogene

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator

  • Anniek Zaalberg1
  • Audrey Lacoste1
  • Emma Minnee1
  • Isabel Mayayo‐Peralta1
  • Karianne G. Schuurman1
  • Sebastian Gregoricchio1
  • Thijs van Schaik1,2
  • Liesbeth Hoekman2,3,4
  • Dapei Li5,6,7
  • Eva Corey8,9
  • Hans Janssen9,10
  • Cor Lieftink10,1
9 more authors
  • Stefan Preković1,11,2
  • Natalie Proost12,13,14,7,3,4
  • Marieke van de Ven12,10
  • Serge A.L. Zander15,1,16
  • Maarten A. F. Altelaar11,2,17,1
  • Peter S. Nelson18,19,8,5,6
  • Roderick L. Beijersbergen10
  • Wilbert T. Zwart20,21
  • Andries Marinus Bergman22,23
23 affiliations
  1. 1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  2. 2Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  3. 3Division of Clinical Research, Fred Hutchinson Cancer Center, University of Washington, Seattle, Washington, USA
  4. 4Division of Human Biology, Fred Hutchinson Cancer Center, University of Washington, Seattle, Washington, USA
  5. 5Division of Clinical Research, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA
  6. 6Division of Human Biology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA
  7. 7Department of Urology, University of Washington, Seattle, Washington, USA
  8. 8Department of Urology, University of Washington, Seattle, WA, USA
  9. 9Electron Microscopy Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  10. 10Division of Molecular Carcinogenesis, The NKI Robotics and Screening Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  11. 11Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht Institute for Pharmaceutical Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
  12. 12Mouse Cancer Clinic, Preclinical Intervention Unit, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  13. 13Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA
  14. 14Department of Medicine, University of Washington, Seattle, Washington, USA
  15. 15Experimental Animal Pathology facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  16. 16Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
  17. 17Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  18. 18Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA
  19. 19Department of Medicine, University of Washington, Seattle, WA, USA
  20. 20Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. [email protected]
  21. 21Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. [email protected]
  22. 22Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. [email protected]
  23. 23Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. [email protected]
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Cite

BibTeXRIS
BibTeX
@article{zaalberg2026genomewide,
  title = {{A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator}},
  author = {Anniek Zaalberg and Audrey Lacoste and Emma Minnee and Isabel Mayayo‐Peralta and Karianne G. Schuurman and Sebastian Gregoricchio and Thijs van Schaik and Liesbeth Hoekman and Dapei Li and Eva Corey and Hans Janssen and Cor Lieftink and Stefan Preković and Natalie Proost and Marieke van de Ven and Serge A.L. Zander and Maarten A. F. Altelaar and Peter S. Nelson and Roderick L. Beijersbergen and Wilbert T. Zwart and Andries Marinus Bergman},
  journal = {Oncogene},
  year = {2026},
  month = jul,
  doi = {10.1038/s41388-026-03912-8},
  url = {https://doi.org/10.1101/2023.06.06.543873},
}
RIS
TY  - JOUR
TI  - A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator
AU  - Anniek Zaalberg
AU  - Audrey Lacoste
AU  - Emma Minnee
AU  - Isabel Mayayo‐Peralta
AU  - Karianne G. Schuurman
AU  - Sebastian Gregoricchio
AU  - Thijs van Schaik
AU  - Liesbeth Hoekman
AU  - Dapei Li
AU  - Eva Corey
AU  - Hans Janssen
AU  - Cor Lieftink
AU  - Stefan Preković
AU  - Natalie Proost
AU  - Marieke van de Ven
AU  - Serge A.L. Zander
AU  - Maarten A. F. Altelaar
AU  - Peter S. Nelson
AU  - Roderick L. Beijersbergen
AU  - Wilbert T. Zwart
AU  - Andries Marinus Bergman
PY  - 2026
DA  - 2026/07/28
JO  - Oncogene
DO  - 10.1038/s41388-026-03912-8
UR  - https://doi.org/10.1101/2023.06.06.543873
SN  - 0950-9232
SN  - 1476-5594
ER  -