Marked Hypergastrinemia and Extreme Erythrocyte Sedimentation Rate Elevation in Autoimmune Atrophic Gastritis with Severe Iron Deficiency Anemia: A Case Report
- 1Faculty of Medicine and Health Sciences An‐Najah National University Nablus Palestine
- 2Department of Internal Medicine Palestine Medical Complex Ramallah Palestine
Abstract
Autoimmune atrophic gastritis causes loss of oxyntic glands, reduced acid secretion, compensatory hypergastrinemia, and impaired iron and vitamin B12 absorption. A 46‐year‐old woman with minimal gastrointestinal symptoms had fasting serum gastrin > 1800 ng/L, an erythrocyte sedimentation rate of 109 mm/h, hemoglobin 8.2 g/dL, and microcytosis. Anti‐parietal cell and intrinsic factor antibodies were positive. Endoscopy and Sydney‐protocol biopsies showed oxyntic‐restricted atrophy, preserved antral mucosa, and linear‐to‐micronodular enterochromaffin‐like‐cell hyperplasia; C‐reactive protein was normal, and computed tomography showed no pancreatic or duodenal mass. After iron and vitamin B12 replacement, hemoglobin rose to 11.0 g/dL, and the erythrocyte sedimentation rate fell to 60 mm/h, whereas gastrin remained > 1800 ng/L at the measured 12‐week follow‐up. The findings support autoimmune atrophic gastritis as the explanation for the hypergastrinemia and an anemia‐associated contribution to the raised erythrocyte sedimentation rate. This case reinforces the need to interpret severe hypergastrinemia in relation to gastric acid status and extreme erythrocyte sedimentation rate values in relation to hematological factors.
Related
- Too slow Erythrocyte Sedimentation Rate: Deeper biophysical understanding, novel accurate parameters and new medical applications
- Association of Plasma CCDC88A Expression Combined with Erythrocyte Sedimentation Rate with Rheumatoid Arthritis Disease Activity: A Cross-Sectional Exploratory Study.
- Usefulness of the C-reactive Protein Level as a Substitute for the Erythrocyte Sedimentation Rate when Calculating the BACES Score of Patients with Mycobacterium Avium Complex Pulmonary Disease
- Genetic diversity of Plasmodium vivax apical membrane antigen 1 (PvAMA1) and erythrocyte binding protein (PvEBP) from malaria endemic areas of Pakistan
- Functional thiamine status in cord blood of near-term gestational women in Northeast India: an erythrocyte transketolase activity coefficient-based cross-sectional study
BibTeX
@article{taha2026marked,
title = {{Marked Hypergastrinemia and Extreme Erythrocyte Sedimentation Rate Elevation in Autoimmune Atrophic Gastritis with Severe Iron Deficiency Anemia: A Case Report}},
author = {Hatem Mousa Taha and Khaled Hatem Taha},
journal = {Clinical case reports},
year = {2026},
month = nov,
doi = {10.1002/ccr3.73865},
url = {https://europepmc.org/article/PMC/PMC13729736},
note = {CC BY},
}
RIS
TY - JOUR
TI - Marked Hypergastrinemia and Extreme Erythrocyte Sedimentation Rate Elevation in Autoimmune Atrophic Gastritis with Severe Iron Deficiency Anemia: A Case Report
AU - Hatem Mousa Taha
AU - Khaled Hatem Taha
PY - 2026
DA - 2026/11/01
JO - Clinical case reports
DO - 10.1002/ccr3.73865
UR - https://europepmc.org/article/PMC/PMC13729736
AB - Autoimmune atrophic gastritis causes loss of oxyntic glands, reduced acid secretion, compensatory hypergastrinemia, and impaired iron and vitamin B12 absorption. A 46‐year‐old woman with minimal gastrointestinal symptoms had fasting serum gastrin > 1800 ng/L, an erythrocyte sedimentation rate of 109 mm/h, hemoglobin 8.2 g/dL, and microcytosis. Anti‐parietal cell and intrinsic factor antibodies were positive. Endoscopy and Sydney‐protocol biopsies showed oxyntic‐restricted atrophy, preserved antral mucosa, and linear‐to‐micronodular enterochromaffin‐like‐cell hyperplasia; C‐reactive protein was normal, and computed tomography showed no pancreatic or duodenal mass. After iron and vitamin B12 replacement, hemoglobin rose to 11.0 g/dL, and the erythrocyte sedimentation rate fell to 60 mm/h, whereas gastrin remained > 1800 ng/L at the measured 12‐week follow‐up. The findings support autoimmune atrophic gastritis as the explanation for the hypergastrinemia and an anemia‐associated contribution to the raised erythrocyte sedimentation rate. This case reinforces the need to interpret severe hypergastrinemia in relation to gastric acid status and extreme erythrocyte sedimentation rate values in relation to hematological factors.
SN - 2050-0904
ER -