Quantitative changes in monoamines in visual brain structures (visual cortex, colliculus superior, and lateral geniculate dorsales) in an experimental model of retinal pigmentary dystrophy
- 1Living Systems Research Institute
Abstract
Introduction. Retinal pigment dystrophy is characterized not only by degeneration of peripheral photoreceptors but also by disruption of neuromodulatory balance in the central structures of the visual analyzer. Purpose. The specific aim of the study was to determine quantitative changes in serotonin (5-HT), norepinephrine (NA), and dopamine (DA) levels in the visual cortex (VC), superior colliculus (CS), and lateral geniculate dorsales (LGD) under experimentally induced retinal pigment dystrophy (RPD). Methods. The study was conducted on rabbits, where a dystrophy model was induced by injection of monoiodoacetic acid. The concentration of monoamines in brain structures was determined using a fluorometric analysis method. Results. Under normal conditions, 5-HT had the highest value (410±7 ng/g in VC, 380±10 ng/g in CS, 405±5 ng/g in LGD). A noticeable increase in 5-HT (420±10 ng/g) and DA (390±10 ng/g) was observed in the CS, while a decrease in 5-HT (365±5 ng/g) and NA (320±10 ng/g) was recorded in the VC. In the LGD, dopamine levels decreased significantly to 310±6 ng/g (p < 0.05). Under experimental retinal pigment dystrophy, significant and structure-specific alterations in monoamine levels were observed in the central visual structures. In the CS, the levels of 5-HT, NA, and DA increased from 380±10 to 420±10 ng/g, from 325±7 to 360±10 ng/g, and from 335±6 to 390±10 ng/g, respectively (p < 0.05). In contrast, DA levels in the LGD decreased from 340±6 to 310±6 ng/g (p < 0.05), while 5-HT levels in the VC decreased from 410±7 to 365±5 ng/g. These findings indicate differential monoaminergic responses across the central visual structures during retinal pigment dystrophy, suggesting that retinal degeneration is accompanied by region-specific alterations in central neuromodulatory mechanisms. The observed changes in 5-HT-ergic, NA-ergic, and DO-ergic systems may reflect adaptive and/or compensatory processes associated with impaired retinal input and altered central–peripheral visual integration. Preservation of monoaminergic homeostasis within the central visual system may therefore represent an important consideration in strategies aimed at maintaining neuronal function and visual processing under dystrophic conditions.
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BibTeX
@article{miryusifova2026quantitative,
title = {{Quantitative changes in monoamines in visual brain structures (visual cortex, colliculus superior, and lateral geniculate dorsales) in an experimental model of retinal pigmentary dystrophy}},
author = {Khuraman Miryusifova and Arzu Allahverdiyeva and Nigar Huseynova and Gunay Malikova and Kamala Cavadova and Alipanah Huseynov and Gulsum Abdullayeva and Sabina Shahmaliyeva and Gunel Valiyeva},
journal = {Ukrainian Journal of Ophthalmology},
year = {2026},
month = oct,
doi = {10.31288/ukr.j.ophthalmol.202655459},
url = {https://doi.org/10.31288/ukr.j.ophthalmol.202655459},
note = {CC BY},
}
RIS
TY - JOUR
TI - Quantitative changes in monoamines in visual brain structures (visual cortex, colliculus superior, and lateral geniculate dorsales) in an experimental model of retinal pigmentary dystrophy
AU - Khuraman Miryusifova
AU - Arzu Allahverdiyeva
AU - Nigar Huseynova
AU - Gunay Malikova
AU - Kamala Cavadova
AU - Alipanah Huseynov
AU - Gulsum Abdullayeva
AU - Sabina Shahmaliyeva
AU - Gunel Valiyeva
PY - 2026
DA - 2026/10/01
JO - Ukrainian Journal of Ophthalmology
DO - 10.31288/ukr.j.ophthalmol.202655459
UR - https://doi.org/10.31288/ukr.j.ophthalmol.202655459
AB - Introduction. Retinal pigment dystrophy is characterized not only by degeneration of peripheral photoreceptors but also by disruption of neuromodulatory balance in the central structures of the visual analyzer. Purpose. The specific aim of the study was to determine quantitative changes in serotonin (5-HT), norepinephrine (NA), and dopamine (DA) levels in the visual cortex (VC), superior colliculus (CS), and lateral geniculate dorsales (LGD) under experimentally induced retinal pigment dystrophy (RPD). Methods. The study was conducted on rabbits, where a dystrophy model was induced by injection of monoiodoacetic acid. The concentration of monoamines in brain structures was determined using a fluorometric analysis method. Results. Under normal conditions, 5-HT had the highest value (410±7 ng/g in VC, 380±10 ng/g in CS, 405±5 ng/g in LGD). A noticeable increase in 5-HT (420±10 ng/g) and DA (390±10 ng/g) was observed in the CS, while a decrease in 5-HT (365±5 ng/g) and NA (320±10 ng/g) was recorded in the VC. In the LGD, dopamine levels decreased significantly to 310±6 ng/g (p < 0.05). Under experimental retinal pigment dystrophy, significant and structure-specific alterations in monoamine levels were observed in the central visual structures. In the CS, the levels of 5-HT, NA, and DA increased from 380±10 to 420±10 ng/g, from 325±7 to 360±10 ng/g, and from 335±6 to 390±10 ng/g, respectively (p < 0.05). In contrast, DA levels in the LGD decreased from 340±6 to 310±6 ng/g (p < 0.05), while 5-HT levels in the VC decreased from 410±7 to 365±5 ng/g. These findings indicate differential monoaminergic responses across the central visual structures during retinal pigment dystrophy, suggesting that retinal degeneration is accompanied by region-specific alterations in central neuromodulatory mechanisms. The observed changes in 5-HT-ergic, NA-ergic, and DO-ergic systems may reflect adaptive and/or compensatory processes associated with impaired retinal input and altered central–peripheral visual integration. Preservation of monoaminergic homeostasis within the central visual system may therefore represent an important consideration in strategies aimed at maintaining neuronal function and visual processing under dystrophic conditions.
SN - 3083-7197
SN - 3083-7200
ER -