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Peer-reviewedCC BY-NC 4.0ARYA Atherosclerosis

The Value of NOX3 Gene Polymorphism (Rs3749930) To Predict Lower Overall Survival of Patients with Abdominal Aortic Aneurysm Undergoing Endovascular Aneurysm Repairing Surgery

  • Hidayet Demir1
  • Mehmet Altuğ Tunçer1
  • Mehrdad Sheikhvatan1
  • Sumaia M. Abuqalben1
  1. 1Cardiovascular Surgery Research Center, Istanbul Okan University, Istanbul, Turkey
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Abstract

BACKGROUND:: Due to the relationship between changes in NOX3 gene expression and production of reactive oxygen species (ROS) activity, as well as the correlation between ROS activity and the occurrence of abdominal aortic aneurysm (AAA), this study proposed the hypothesis for the first time that the occurrence of rs3749930 polymorphism in the NOX3 gene may predict adverse outcomes in patients with AAA undergoing endovascular aneurysm repairing (EVAR) surgery.

METHODS:: The study participants included 1092 patients aged higher than 18 years suffered from AAA and candidate for EVAR. The Kompetitive Allele Specific polymerase chain reaction (KASP) method was used to genotyping the rs3749930 polymorphism in the NOX3 gene. The mean follow-up time of the patients was 6.6 years to assess post-procedural long-term outcome.

RESULTS:: The prevalence of G and T alleles in the study population was found to be 86.3% and 13.7% respectively. The prevalence of G and T alleles in died patients 93.0% and 7.0% and in survived patients was 83.2% and 16.8% respectively indicating a significant difference (P = 0.012). The 5-year overall survival in patients with the GG variant of rs3749930 polymorphism 58.6% and in those with GT+TT genotype was 73.4%. According to Cox proportional hazard modeling, the presence of GG variant along with older age, female gender, history of renal dysfunction, and higher aneurysm diameter were the correlates of long-term death.

CONCLUSION:: Tracking the presence of G dominant allele of NOX3 gene polymorphism (rs3749930) can predict lower overall survival following EVAR surgery.

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Cite

BibTeXRIS
BibTeX
@article{demir2026value,
  title = {{The Value of NOX3 Gene Polymorphism (Rs3749930) To Predict Lower Overall Survival of Patients with Abdominal Aortic Aneurysm Undergoing Endovascular Aneurysm Repairing Surgery}},
  author = {Hidayet Demir and Mehmet Altuğ Tunçer and Mehrdad Sheikhvatan and Sumaia M. Abuqalben},
  journal = {ARYA Atherosclerosis},
  year = {2026},
  month = oct,
  doi = {10.48305/arya.2026.45423.3072},
  url = {https://doi.org/10.48305/arya.2026.45423.3072},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - The Value of NOX3 Gene Polymorphism (Rs3749930) To Predict Lower Overall Survival of Patients with Abdominal Aortic Aneurysm Undergoing Endovascular Aneurysm Repairing Surgery
AU  - Hidayet Demir
AU  - Mehmet Altuğ Tunçer
AU  - Mehrdad Sheikhvatan
AU  - Sumaia M. Abuqalben
PY  - 2026
DA  - 2026/10/30
JO  - ARYA Atherosclerosis
DO  - 10.48305/arya.2026.45423.3072
UR  - https://doi.org/10.48305/arya.2026.45423.3072
AB  - BACKGROUND:: Due to the relationship between changes in NOX3 gene expression and production of reactive oxygen species (ROS) activity, as well as the correlation between ROS activity and the occurrence of abdominal aortic aneurysm (AAA), this study proposed the hypothesis for the first time that the occurrence of rs3749930 polymorphism in the NOX3 gene may predict adverse outcomes in patients with AAA undergoing endovascular aneurysm repairing (EVAR) surgery.  METHODS:: The study participants included 1092 patients aged higher than 18 years suffered from AAA and candidate for EVAR. The Kompetitive Allele Specific polymerase chain reaction (KASP) method was used to genotyping the rs3749930 polymorphism in the NOX3 gene. The mean follow-up time of the patients was 6.6 years to assess post-procedural long-term outcome.  RESULTS:: The prevalence of G and T alleles in the study population was found to be 86.3% and 13.7% respectively. The prevalence of G and T alleles in died patients 93.0% and 7.0% and in survived patients was 83.2% and 16.8% respectively indicating a significant difference (P = 0.012). The 5-year overall survival in patients with the GG variant of rs3749930 polymorphism 58.6% and in those with GT+TT genotype was 73.4%. According to Cox proportional hazard modeling, the presence of GG variant along with older age, female gender, history of renal dysfunction, and higher aneurysm diameter were the correlates of long-term death.  CONCLUSION:: Tracking the presence of G dominant allele of NOX3 gene polymorphism (rs3749930) can predict lower overall survival following EVAR surgery.
SN  - 1735-3955
SN  - 2251-6638
ER  -