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Peer-reviewedCC BYInterdisciplinary Neurosurgery

Analysis of factors influencing short-term prognosis in patients with chronic subdural hematoma: A single-center retrospective cohort study

  • Hucheng Wang1
  • Xiaoliang Yang
  • Ming Zhao2
  • Rongjun Zhang1
  • Helong Wang3
  • Le Gao3
  • Nan Liu3
  • Xiaoxuan Fan4
  • Guoyi Gao5
5 affiliations
  1. 1Department of Neurosurgery, The 987th Hospital of Joint Logistics Support Force, People's Liberation Army, Baoji, Shaanxi Province, 721004, China
  2. 2Department of Neurosurgery, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China
  3. 3Department of Emergency Medicine, The 987th Hospital of Joint Logistics Support Force, People's Liberation Army, Baoji, Shaanxi Province, 721004, China
  4. 4Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China
  5. 5Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China
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Abstract

Background: Chronic subdural hematoma (CSDH) is a common condition with variable postoperative outcomes. This study aimed to evaluate the influence of demographic, clinical, and novel inflammatory/metabolic parameters on short-term prognosis in CSDH patients. Methods: A single-center retrospective cohort study was conducted on 516 adult patients with CSDH between January 2015 and December 2025. Outcomes included in-hospital mortality, symptomatic recurrence requiring reoperation within 30 days, and length of hospital stay (LOS). Multivariate analyses were performed using Firth logistic regression for rare events and linear regression for LOS. Results: In-hospital death occurred in 7 patients (1.4%), and recurrence in 26 patients (5.0%). Multivariate Firth regression identified lower GCS score (OR = 0.68 per point, 95% CI 0.53–0.85, P = 0.001) and older age (OR = 1.10 per year, 95% CI 1.01–1.25, P = 0.032) as independent predictors of mortality. Right-sided hematoma (vs. left) was independently associated with lower recurrence risk (OR = 0.08, 95% CI 0.00–0.87, P = 0.036). Higher platelet count (β = 0.025, P < 0.001), coronary heart disease (β = 2.01, P = 0.025), and higher INR (β = 8.76, P = 0.002) were independently associated with prolonged LOS. Conclusions: Baseline neurological status and age are critical determinants of short-term mortality in CSDH. Hematoma laterality predicts recurrence, while platelet count, INR, and coronary heart disease predict resource utilization. The prognostic role of the TyG index was not statistically significant in this cohort and warrants further investigation.

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Cite

BibTeXRIS
BibTeX
@article{wang2026analysis,
  title = {{Analysis of factors influencing short-term prognosis in patients with chronic subdural hematoma: A single-center retrospective cohort study}},
  author = {Hucheng Wang and Xiaoliang Yang and Ming Zhao and Rongjun Zhang and Helong Wang and Le Gao and Nan Liu and Xiaoxuan Fan and Guoyi Gao},
  journal = {Interdisciplinary Neurosurgery},
  year = {2026},
  month = oct,
  doi = {10.1016/j.inat.2026.102399},
  url = {https://doi.org/10.1016/j.inat.2026.102399},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Analysis of factors influencing short-term prognosis in patients with chronic subdural hematoma: A single-center retrospective cohort study
AU  - Hucheng Wang
AU  - Xiaoliang Yang
AU  - Ming Zhao
AU  - Rongjun Zhang
AU  - Helong Wang
AU  - Le Gao
AU  - Nan Liu
AU  - Xiaoxuan Fan
AU  - Guoyi Gao
PY  - 2026
DA  - 2026/10/30
JO  - Interdisciplinary Neurosurgery
DO  - 10.1016/j.inat.2026.102399
UR  - https://doi.org/10.1016/j.inat.2026.102399
AB  - Background: Chronic subdural hematoma (CSDH) is a common condition with variable postoperative outcomes. This study aimed to evaluate the influence of demographic, clinical, and novel inflammatory/metabolic parameters on short-term prognosis in CSDH patients. Methods: A single-center retrospective cohort study was conducted on 516 adult patients with CSDH between January 2015 and December 2025. Outcomes included in-hospital mortality, symptomatic recurrence requiring reoperation within 30 days, and length of hospital stay (LOS). Multivariate analyses were performed using Firth logistic regression for rare events and linear regression for LOS. Results: In-hospital death occurred in 7 patients (1.4%), and recurrence in 26 patients (5.0%). Multivariate Firth regression identified lower GCS score (OR = 0.68 per point, 95% CI 0.53–0.85, P = 0.001) and older age (OR = 1.10 per year, 95% CI 1.01–1.25, P = 0.032) as independent predictors of mortality. Right-sided hematoma (vs. left) was independently associated with lower recurrence risk (OR = 0.08, 95% CI 0.00–0.87, P = 0.036). Higher platelet count (β = 0.025, P < 0.001), coronary heart disease (β = 2.01, P = 0.025), and higher INR (β = 8.76, P = 0.002) were independently associated with prolonged LOS. Conclusions: Baseline neurological status and age are critical determinants of short-term mortality in CSDH. Hematoma laterality predicts recurrence, while platelet count, INR, and coronary heart disease predict resource utilization. The prognostic role of the TyG index was not statistically significant in this cohort and warrants further investigation.
SN  - 2214-7519
ER  -