New Perspectives in Prevention, Control, and Treatment of Dengue Fever.
4 affiliations
- 1Faculty of Health Sciences, Universidad de la Guajira, Riohach 440002, Colombia.
- 2Faculty of Health, Exact and Natural Sciences, Universidad Libre Seccional Barranquilla, Barranquilla 081001, Colombia.
- 3Faculty of Medicine, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44350, Mexico.
- 4Department of Medicine, Foggy Bottom Campus, George Washington University, Washington 20052, DC, USA.
Abstract
Dengue is a mosquito-borne viral disease primarily transmitted by Aedes aegypti and is endemic in tropical and subtropical regions worldwide. It represents a major global public health challenge because of its rapid expansion and increasing incidence. Clinical manifestations range from mild febrile illness to severe disease with hemorrhage and death. No specific antiviral treatment exists, and prevention has relied on vector control to reduce human-mosquito contact. Although vaccines are available, access remains limited. In the Americas, dengue transmission has intensified markedly in recent years. The largest epidemic occurred in 2024, with more than 12.6 million cases and over 7700 deaths. In 2025, reports showed 4 million suspected cases, including 8966 severe cases and 2207 deaths. This persistent burden may be driven by climate variability, urbanization, mobility, environmental change, and widespread vector distribution, all of which contribute to ongoing transmission and disease severity. These trends underscore the critical need to strengthen surveillance, improve integrated vector management, expand vaccine access, and develop effective therapies to reduce the health, social, and economic impact of this disease. Accordingly, effective preventive and therapeutic strategies are needed to address this persistent and growing threat.
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BibTeX
@article{castellarlopez2026perspectives,
title = {{New Perspectives in Prevention, Control, and Treatment of Dengue Fever.}},
author = {Jairo Castellar-Lopez and Yeini Julieth Gutiérrez Rodríguez and Gabriela Alejandra Cáceres and Monica Gomez Pulido and Gabriela Lara Barreto and Noemi Ramirez and Santiago Alcazar Santos and Marian Mares Blancas and Diego Castro Garcia and Joseph León Insignares and Vanessa Cohen Ariza and Vanessa Gamarra Nicoliche and Wendy Rosales and Ronald Maestre-Serrano and Aileen Y Chang and Evelyn Mendoza-Torres},
journal = {Viruses},
year = {2026},
month = oct,
doi = {10.3390/v18101162},
url = {https://europepmc.org/article/MED/42944081},
note = {CC BY},
}
RIS
TY - JOUR
TI - New Perspectives in Prevention, Control, and Treatment of Dengue Fever.
AU - Jairo Castellar-Lopez
AU - Yeini Julieth Gutiérrez Rodríguez
AU - Gabriela Alejandra Cáceres
AU - Monica Gomez Pulido
AU - Gabriela Lara Barreto
AU - Noemi Ramirez
AU - Santiago Alcazar Santos
AU - Marian Mares Blancas
AU - Diego Castro Garcia
AU - Joseph León Insignares
AU - Vanessa Cohen Ariza
AU - Vanessa Gamarra Nicoliche
AU - Wendy Rosales
AU - Ronald Maestre-Serrano
AU - Aileen Y Chang
AU - Evelyn Mendoza-Torres
PY - 2026
DA - 2026/10/19
JO - Viruses
DO - 10.3390/v18101162
UR - https://europepmc.org/article/MED/42944081
AB - Dengue is a mosquito-borne viral disease primarily transmitted by Aedes aegypti and is endemic in tropical and subtropical regions worldwide. It represents a major global public health challenge because of its rapid expansion and increasing incidence. Clinical manifestations range from mild febrile illness to severe disease with hemorrhage and death. No specific antiviral treatment exists, and prevention has relied on vector control to reduce human-mosquito contact. Although vaccines are available, access remains limited. In the Americas, dengue transmission has intensified markedly in recent years. The largest epidemic occurred in 2024, with more than 12.6 million cases and over 7700 deaths. In 2025, reports showed 4 million suspected cases, including 8966 severe cases and 2207 deaths. This persistent burden may be driven by climate variability, urbanization, mobility, environmental change, and widespread vector distribution, all of which contribute to ongoing transmission and disease severity. These trends underscore the critical need to strengthen surveillance, improve integrated vector management, expand vaccine access, and develop effective therapies to reduce the health, social, and economic impact of this disease. Accordingly, effective preventive and therapeutic strategies are needed to address this persistent and growing threat.
SN - 1999-4915
ER -