Angioimmunoblastic T-cell lymphoma following Castleman’s disease: diagnostic challenges and literature review
- 1Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310006 China
Abstract
Castleman disease (CD) represents a heterogeneous group of hematologic disorders characterized by distinct histopathological features. While CD is regarded as a pre-lymphomatous condition, its reactive or neoplastic nature is still a matter of controversy. Although rare, lymphoma has been reported in patients with CD, most commonly B-cell lymphomas. Here, we present a case of a 69-year-old man initially diagnosed with CD who subsequently developed angioimmunoblastic T-cell lymphoma (AITL) during treatment. To elucidate the potential biological relationship between these two disease entities, we performed whole-exome sequencing to compare genomic alterations between the two disease states. Additionally, we provide a concise review of published cases documenting lymphoma occurring after or coexisting with CD, summarizing patients’ characteristics and the various treatment strategies employed thus far.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00277-026-07199-3.
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BibTeX
@article{xu2026angioimmunoblastic,
title = {{Angioimmunoblastic T-cell lymphoma following Castleman’s disease: diagnostic challenges and literature review}},
author = {Ruyi Xu and Xi Huang and Jia Hu and Jinuo Wang and Duoduo Zhao and Xiaoyan Han and Zhen Cai and Wenjun Wu},
journal = {Annals of Hematology},
year = {2026},
month = jul,
doi = {10.1007/s00277-026-07199-3},
url = {https://doi.org/10.1007/s00277-026-07199-3},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Angioimmunoblastic T-cell lymphoma following Castleman’s disease: diagnostic challenges and literature review
AU - Ruyi Xu
AU - Xi Huang
AU - Jia Hu
AU - Jinuo Wang
AU - Duoduo Zhao
AU - Xiaoyan Han
AU - Zhen Cai
AU - Wenjun Wu
PY - 2026
DA - 2026/07/01
JO - Annals of Hematology
DO - 10.1007/s00277-026-07199-3
UR - https://doi.org/10.1007/s00277-026-07199-3
AB - Castleman disease (CD) represents a heterogeneous group of hematologic disorders characterized by distinct histopathological features. While CD is regarded as a pre-lymphomatous condition, its reactive or neoplastic nature is still a matter of controversy. Although rare, lymphoma has been reported in patients with CD, most commonly B-cell lymphomas. Here, we present a case of a 69-year-old man initially diagnosed with CD who subsequently developed angioimmunoblastic T-cell lymphoma (AITL) during treatment. To elucidate the potential biological relationship between these two disease entities, we performed whole-exome sequencing to compare genomic alterations between the two disease states. Additionally, we provide a concise review of published cases documenting lymphoma occurring after or coexisting with CD, summarizing patients’ characteristics and the various treatment strategies employed thus far. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00277-026-07199-3.
SN - 0939-5555
SN - 1432-0584
ER -