Polyproline: A Synthetic Polypeptide With Unique Properties
- 1CNRS Bordeaux INP LCPO UMR 5629 University Bordeaux Pessac France
- 2Department of Chemistry RCSI University of Medcine and Health Sciences Dublin 2 Ireland
Abstract
Polyproline is a unique polypeptide defined by its unusual conformational rigidity and physicochemical behavior. Addressing long‐standing challenges in its synthesis and characterization, this mini‐review highlights recent advances in the ring‐opening polymerization of proline N‐carboxyanhydride (NCA), enabling the controlled and scalable preparation of well‐defined polyproline architectures. These developments have unlocked diverse applications in advanced materials, including systems that exploit intrinsic thermoresponsive behavior arising from conformational transitions, leading to Lower Critical Solution Temperature (LCST)‐type phase separation with pronounced hysteresis. Emerging applications span smart 3D printed hydrogels, nanoparticles, membrane‐active materials, and polyproline‐based conjugates, where polyproline serves as a biocompatible alternative to poly(ethylene glycol) (PEG). Collectively, these advances position polyproline as a promising platform in biomaterials, offering benefits such as enhanced stability, reduced immunogenicity, and expanded functional versatility.
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BibTeX
@article{scouarnec2026polyproline,
title = {{Polyproline: A Synthetic Polypeptide With Unique Properties}},
author = {Rosanna Le Scouarnec and Josué M. Galindo and Colin Bonduelle and Andreas Heise},
journal = {Angewandte Chemie (International Ed. in English)},
year = {2026},
month = sep,
doi = {10.1002/anie.5624080},
url = {https://doi.org/10.1002/anie.5624080},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Polyproline: A Synthetic Polypeptide With Unique Properties
AU - Rosanna Le Scouarnec
AU - Josué M. Galindo
AU - Colin Bonduelle
AU - Andreas Heise
PY - 2026
DA - 2026/09/02
JO - Angewandte Chemie (International Ed. in English)
DO - 10.1002/anie.5624080
UR - https://doi.org/10.1002/anie.5624080
AB - Polyproline is a unique polypeptide defined by its unusual conformational rigidity and physicochemical behavior. Addressing long‐standing challenges in its synthesis and characterization, this mini‐review highlights recent advances in the ring‐opening polymerization of proline N‐carboxyanhydride (NCA), enabling the controlled and scalable preparation of well‐defined polyproline architectures. These developments have unlocked diverse applications in advanced materials, including systems that exploit intrinsic thermoresponsive behavior arising from conformational transitions, leading to Lower Critical Solution Temperature (LCST)‐type phase separation with pronounced hysteresis. Emerging applications span smart 3D printed hydrogels, nanoparticles, membrane‐active materials, and polyproline‐based conjugates, where polyproline serves as a biocompatible alternative to poly(ethylene glycol) (PEG). Collectively, these advances position polyproline as a promising platform in biomaterials, offering benefits such as enhanced stability, reduced immunogenicity, and expanded functional versatility.
SN - 1433-7851
SN - 1521-3773
ER -