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Peer-reviewedCC BY-NC-NDJACC. Case reports

Rapid Native and Bioprosthetic Tricuspid Valve Degeneration in Carcinoid Heart Disease.

  • Lucia Trabucchi1
  • Richiele Forgiarini1
  • Maria I Ardid1
  • Abraham Abdemur2
  • Raul E Herrera1
  • Rodolfo Arce3
  • Tom C Nguyen1
  • Ramon Quesada1
  • Elliott J Elias1
  • Nish Patel1
  1. 1Miami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.
  2. 2Miami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA. Electronic address: [email protected].
  3. 3Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
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Abstract

Background

Carcinoid heart disease (CaHD) is a severe complication of metastatic neuroendocrine tumors characterized by serotonin-mediated fibrotic degeneration of right-sided cardiac valves.Case summary

We present 3 patients with metastatic neuroendocrine tumors complicated by severe carcinoid valvulopathy involving native and prosthetic tricuspid valves. Two patients underwent bioprosthetic tricuspid valve replacement for severe tricuspid regurgitation, including 1 patient who developed rapid recurrent prosthetic valve degeneration requiring transcatheter tricuspid valve-in-valve replacement. A third patient presented with advanced bivalvular carcinoid involvement requiring complex surgical reconstruction complicated by postoperative cardiogenic shock and death.Discussion

These cases illustrate the progressive nature of serotonin-mediated valvular degeneration, challenges in prosthetic valve selection, and the importance of multidisciplinary management and close echocardiographic surveillance in CaHD.Take-home messages

Persistent serotonin exposure may result in rapid degeneration of native and bioprosthetic valves despite surgical intervention. Early recognition and multidisciplinary management are essential to optimize outcomes in CaHD.

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Cite

BibTeXRIS
BibTeX
@article{trabucchi2026rapid,
  title = {{Rapid Native and Bioprosthetic Tricuspid Valve Degeneration in Carcinoid Heart Disease.}},
  author = {Lucia Trabucchi and Richiele Forgiarini and Maria I Ardid and Abraham Abdemur and Raul E Herrera and Rodolfo Arce and Tom C Nguyen and Ramon Quesada and Elliott J Elias and Nish Patel},
  journal = {JACC. Case reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jaccas.2026.110337},
  url = {https://europepmc.org/article/MED/42847575},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Rapid Native and Bioprosthetic Tricuspid Valve Degeneration in Carcinoid Heart Disease.
AU  - Lucia Trabucchi
AU  - Richiele Forgiarini
AU  - Maria I Ardid
AU  - Abraham Abdemur
AU  - Raul E Herrera
AU  - Rodolfo Arce
AU  - Tom C Nguyen
AU  - Ramon Quesada
AU  - Elliott J Elias
AU  - Nish Patel
PY  - 2026
DA  - 2026/10/01
JO  - JACC. Case reports
DO  - 10.1016/j.jaccas.2026.110337
UR  - https://europepmc.org/article/MED/42847575
AB  - Background  Carcinoid heart disease (CaHD) is a severe complication of metastatic neuroendocrine tumors characterized by serotonin-mediated fibrotic degeneration of right-sided cardiac valves.Case summary  We present 3 patients with metastatic neuroendocrine tumors complicated by severe carcinoid valvulopathy involving native and prosthetic tricuspid valves. Two patients underwent bioprosthetic tricuspid valve replacement for severe tricuspid regurgitation, including 1 patient who developed rapid recurrent prosthetic valve degeneration requiring transcatheter tricuspid valve-in-valve replacement. A third patient presented with advanced bivalvular carcinoid involvement requiring complex surgical reconstruction complicated by postoperative cardiogenic shock and death.Discussion  These cases illustrate the progressive nature of serotonin-mediated valvular degeneration, challenges in prosthetic valve selection, and the importance of multidisciplinary management and close echocardiographic surveillance in CaHD.Take-home messages  Persistent serotonin exposure may result in rapid degeneration of native and bioprosthetic valves despite surgical intervention. Early recognition and multidisciplinary management are essential to optimize outcomes in CaHD.
SN  - 2666-0849
ER  -