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Peer-reviewedCC BYOrthopaedic Journal of Sports Medicine

Hyperbaric Oxygen Therapy Improves Early Graft Healing Following ACL Reconstruction with Hamstring Autografts

  • C.B.G. Leite1
  • D. Meirelles2
  • L.R. Morimoto3
  • A.G. Ormond Filho3
  • C.O.D. Elia2
  • M.K. Demange1
  1. 1IOT HCFMUSP, SÃO PAULO - SP – BRASIL
  2. 2INSTITUTO VITA, SÃO PAULO - SP – BRASIL
  3. 3FLEURY MEDICINA E SAÚDE, SÃO PAULO - SP - BRASIL
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Abstract

Objectives: To evaluate the impact of hyperbaric oxygen therapy on graft maturation and integration in patients undergoing anterior cruciate ligament (ACL) reconstruction, using magnetic resonance imaging (MRI) performed 4 months postoperatively. Methods: Patients who underwent primary anatomic ACL reconstruction with hamstring autografts and adjunctive hyperbaric oxygen therapy were identified and matched 1:1 by sex and age categories (<25, 25–39, 40–54, and >55 years) with controls who did not receive hyperbaric oxygen therapy. MRI was performed at 4 months postoperatively. Graft maturation was assessed using the signal-to-noise quotient (SNQ), and bone marrow edema adjacent to the graft–bone tunnel interface was graded as absent, mild, or accentuated as an indirect marker of graft integration. Results: A total of 52 patients were included (26 hyperbaric oxygen therapy, 26 controls), with a mean age of 37.0 ± 13.5 years and 61.5% male. The hyperbaric oxygen therapy group demonstrated significantly lower graft SNQ compared with controls (median difference = 83.9; p = 0.031), indicating improved graft maturation. Bone marrow edema adjacent to the graft–bone tunnel interface was also significantly lower in the hyperbaric oxygen therapy group (p = 0.029), suggesting enhanced graft integration. Conclusion: Hyperbaric oxygen therapy following ACL reconstruction was associated with significantly improved early signs of graft maturation and integration on MRI at 4 months, suggesting that it may accelerate the early phases of graft healing.

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Cite

BibTeXRIS
BibTeX
@article{leite2026hyperbaric,
  title = {{Hyperbaric Oxygen Therapy Improves Early Graft Healing Following ACL Reconstruction with Hamstring Autografts}},
  author = {C.B.G. Leite and D. Meirelles and L.R. Morimoto and A.G. Ormond Filho and C.O.D. Elia and M.K. Demange},
  journal = {Orthopaedic Journal of Sports Medicine},
  year = {2026},
  month = oct,
  doi = {10.1177/2325967126s00621},
  url = {https://doi.org/10.1177/2325967126s00621},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Hyperbaric Oxygen Therapy Improves Early Graft Healing Following ACL Reconstruction with Hamstring Autografts
AU  - C.B.G. Leite
AU  - D. Meirelles
AU  - L.R. Morimoto
AU  - A.G. Ormond Filho
AU  - C.O.D. Elia
AU  - M.K. Demange
PY  - 2026
DA  - 2026/10/28
JO  - Orthopaedic Journal of Sports Medicine
DO  - 10.1177/2325967126s00621
UR  - https://doi.org/10.1177/2325967126s00621
AB  - Objectives: To evaluate the impact of hyperbaric oxygen therapy on graft maturation and integration in patients undergoing anterior cruciate ligament (ACL) reconstruction, using magnetic resonance imaging (MRI) performed 4 months postoperatively. Methods: Patients who underwent primary anatomic ACL reconstruction with hamstring autografts and adjunctive hyperbaric oxygen therapy were identified and matched 1:1 by sex and age categories (<25, 25–39, 40–54, and >55 years) with controls who did not receive hyperbaric oxygen therapy. MRI was performed at 4 months postoperatively. Graft maturation was assessed using the signal-to-noise quotient (SNQ), and bone marrow edema adjacent to the graft–bone tunnel interface was graded as absent, mild, or accentuated as an indirect marker of graft integration. Results: A total of 52 patients were included (26 hyperbaric oxygen therapy, 26 controls), with a mean age of 37.0 ± 13.5 years and 61.5% male. The hyperbaric oxygen therapy group demonstrated significantly lower graft SNQ compared with controls (median difference = 83.9; p = 0.031), indicating improved graft maturation. Bone marrow edema adjacent to the graft–bone tunnel interface was also significantly lower in the hyperbaric oxygen therapy group (p = 0.029), suggesting enhanced graft integration. Conclusion: Hyperbaric oxygen therapy following ACL reconstruction was associated with significantly improved early signs of graft maturation and integration on MRI at 4 months, suggesting that it may accelerate the early phases of graft healing.
SN  - 2325-9671
ER  -