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Peer-reviewedCC BYInternational journal of medical sciences

The relationship between 5α-reductase inhibitors and the presence of following open angle glaucoma: a TriNetX cohort study.

  • Chia-Yi Lee1,2,3
  • Shun-Fa Yang1,4
  • Shih-Chi Su5
  • Yu-Ling Chang6
  • Jing-Yang Huang4
  • Chao-Bin Yeh7,8
  • Po-Hsien Huang9
  • Chao-Kai Chang3,10
10 affiliations
  1. 1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  2. 2Cerulean Eye Center, Taichung, Taiwan.
  3. 3Nobel Eye Institute, Taipei, Taiwan.
  4. 4Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
  5. 5Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan.
  6. 6Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan.
  7. 7Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  8. 8Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
  9. 9Kaohsiung Nobel Eye Institute, Kaohsiung, Taiwan.
  10. 10Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
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Abstract

Purpose

This study was conducted to test a possible association between 5α-reductase inhibitor (5ARI) use and subsequent open-angle glaucoma (OAG).Method

A retrospective cohort study was conducted, and individuals with benign prostate hyperplasia (BPH) and androgenetic alopecia were included and classified according to whether they received 5ARI treatment. A total of 181,208 individuals were included in each of the 5ARI and non-5ARI groups. The primary outcome was the development of OAG according to diagnostic and procedure codes. Cox proportional hazard regression was performed for the statistical analysis.Results

OAG occurred in 3477 patients (5.14%) in the 5ARI group and 3044 patients (4.59%) in the non-5ARI group. After adjustment for multiple covariates, exposure to 5ARIs was associated with a significantly greater risk of OAG compared with the non-5ARI treatment (P < 0.001). The cumulative incidence of OAG was significantly higher among patients receiving 5ARI therapy than among those in the non-5ARI group (P < 0.001), and the cumulative incidence of HTG was significantly higher in the 5ARI population than the non-5ARI population (P = 0.002). In the sensitivity analysis, the 5ARI cohort exhibited significantly increased rates of OAG and HTG compared with the non-5ARI cohort, except for Asian individuals (P > 0.05).Conclusions

The use of 5ARIs may be related to the development of OAG.

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Cite

BibTeXRIS
BibTeX
@article{lee2026relationship,
  title = {{The relationship between 5α-reductase inhibitors and the presence of following open angle glaucoma: a TriNetX cohort study.}},
  author = {Chia-Yi Lee and Shun-Fa Yang and Shih-Chi Su and Yu-Ling Chang and Jing-Yang Huang and Chao-Bin Yeh and Po-Hsien Huang and Chao-Kai Chang},
  journal = {International journal of medical sciences},
  year = {2026},
  month = oct,
  doi = {10.7150/ijms.137426},
  url = {https://europepmc.org/article/MED/42910139},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The relationship between 5α-reductase inhibitors and the presence of following open angle glaucoma: a TriNetX cohort study.
AU  - Chia-Yi Lee
AU  - Shun-Fa Yang
AU  - Shih-Chi Su
AU  - Yu-Ling Chang
AU  - Jing-Yang Huang
AU  - Chao-Bin Yeh
AU  - Po-Hsien Huang
AU  - Chao-Kai Chang
PY  - 2026
DA  - 2026/10/02
JO  - International journal of medical sciences
DO  - 10.7150/ijms.137426
UR  - https://europepmc.org/article/MED/42910139
AB  - Purpose  This study was conducted to test a possible association between 5α-reductase inhibitor (5ARI) use and subsequent open-angle glaucoma (OAG).Method  A retrospective cohort study was conducted, and individuals with benign prostate hyperplasia (BPH) and androgenetic alopecia were included and classified according to whether they received 5ARI treatment. A total of 181,208 individuals were included in each of the 5ARI and non-5ARI groups. The primary outcome was the development of OAG according to diagnostic and procedure codes. Cox proportional hazard regression was performed for the statistical analysis.Results  OAG occurred in 3477 patients (5.14%) in the 5ARI group and 3044 patients (4.59%) in the non-5ARI group. After adjustment for multiple covariates, exposure to 5ARIs was associated with a significantly greater risk of OAG compared with the non-5ARI treatment (P < 0.001). The cumulative incidence of OAG was significantly higher among patients receiving 5ARI therapy than among those in the non-5ARI group (P < 0.001), and the cumulative incidence of HTG was significantly higher in the 5ARI population than the non-5ARI population (P = 0.002). In the sensitivity analysis, the 5ARI cohort exhibited significantly increased rates of OAG and HTG compared with the non-5ARI cohort, except for Asian individuals (P > 0.05).Conclusions  The use of 5ARIs may be related to the development of OAG.
SN  - 1449-1907
ER  -